Results 211 to 220 of about 44,809,382 (241)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reimagining open science for global health: Epistemic power and the pursuit of health equity. [PDF]

PLOS Glob Public Health
Rangel Teixeira A, Kleinlein R, Kalema NL, Agyemang GO, Senteio C, Celi LA, Agyemang S, Kebede MA.   +7 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Artificial Intelligence-Powered Raman Spectroscopy through Open Science and FAIR Principles. [PDF]

ACS Nano
Coca-Lopez N, Alcolea-Rodriguez V, Bañares MA, Brockhauser S, Gorenflot J, Henderson A, Hildebrandt R, Jeliazkova N, Kochev N, Lozano Diz E, Pilat Z, Polli D, Strömert P, Sturm C, Vanna R, Portela R.   +15 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fostering open science and responsible research practices: A pre-post study. [PDF]

F1000Res
Cenci J, Correa MB, Bouter L, Moher D, Bronkhorst E, Franco MC, Mendes FM, Pereira-Cenci T, Huysmans MC, Cenci MS.   +9 more
europepmc   +1 more source

Open Science Practices in Integrated Assessment Models. [PDF]

Open Res Eur
Rodés-Bachs C, Sampedro J, Frilingou N, Gardumi F, Lo Giudice C.   +4 more
europepmc   +1 more source

Open science practices among early-career human-computer interaction researchers in the US. [PDF]

PLoS One
Chakravorti T, Gautam S, Rajtmajer S.
europepmc   +1 more source

Retinal imaging in an era of open science and privacy protection. [PDF]

Exp Eye Res
Gim N, Blazes M, Sánchez CI, Zalunardo L, Corradetti G, Elze T, Honda N, Waheed NK, Cairns AM, Canto-Soler MV, Domalpally A, Durbin M, Ferrara D, Hu J, Nair P, Sadda SR, Keenan TDL, Lee CS, RIMR Consortium.   +18 more
europepmc   +1 more source

Enhancing translational research in metastatic cancer through an open science environment: the UPTIDER experience. [PDF]

NPJ Precis Oncol
Pabba A, Maetens M, Mahdami A, Geukens T, De Schepper M, Zels G, Van Baelen K, Leduc S, Nguyen HL, Van Cauwenberge J, Borremans K, Hatse S, Nysen M, Rousseau E, Di Tommaso A, Boeckx B, Neven P, Wildiers H, Biganzoli E, Vermeulen P, Van Den Bogaert W, Lambrechts D, Floris G, Desmedt C, Richard F.   +24 more
europepmc   +1 more source