Results 241 to 250 of about 2,214,920 (300)

A manifesto for a globally diverse, equitable, and inclusive open science. [PDF]

Commun Psychol
Ghai S, Thériault R, Forscher P, Shoda Y, Syed M, Puthillam A, Peng HC, Basnight-Brown D, Majid A, Azevedo F, Singh L.   +10 more
europepmc   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Disruptive Technologies and Open Science: How Open Should Open Science Be? A 'Third Bioethics' Ethical Framework. [PDF]

Sci Eng Ethics
Spitale G, Germani F, Biller-Andorno N.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Open science interventions to improve reproducibility and replicability of research: a scoping review. [PDF]

R Soc Open Sci
Dudda L, Kormann E, Kozula M, DeVito NJ, Klebel T, Dewi APM, Spijker R, Stegeman I, Van den Eynden V, Ross-Hellauer T, Leeflang MMG.   +10 more
europepmc   +1 more source

Closing Thoughts on the Collective Intelligence of the 2025 Open Science FAIR

Marcum, Christopher
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Advancing open science: The evolving role of preprints in biomedical research. [PDF]

J Spinal Cord Med
Murphy CA, Thomas FP.
europepmc   +1 more source

Open Science self-evaluation model for multidisciplinary universities : Case Finland

Nykyri, Susanna, Niemi, Laura
openalex   +1 more source