Results 301 to 310 of about 15,014,800 (402)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Balancing ethical data sharing and open science for reproducible research in biomedical data science. [PDF]

Cell Rep Med
Lvovs D, Creason AL, Levine SS, Noble M, Mahurkar A, White O, Fertig EJ.   +6 more
europepmc   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment. [PDF]

Front Toxicol
Teunis M, Luechtefeld T, Hartung T.
europepmc   +1 more source

Dan Burk on open-source science

, 2006
Peter Suber
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Open science and translation

Cybergeo, 2020
Christine Kosmopoulos
doaj  

Biological Psychiatry: Global Open Science—Supporting Open Science and Global Diversity in Research

Biological Psychiatry Global Open Science, 2021
Deanna M. Barch
doaj  

Open Science at the generative AI turn: An exploratory analysis of challenges and opportunities. [PDF]

Quant Sci Stud
Hosseini M, Horbach SPJM, Holmes K, Ross-Hellauer T.   +3 more
europepmc   +1 more source

Defining open science

, 2006
Peter Suber
openalex   +1 more source