Results 301 to 310 of about 8,810,905 (348)

Open Science self-evaluation model for multidisciplinary universities : Case Finland

Nykyri, Susanna, Niemi, Laura
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

FAIR assessment of Disease Maps fosters open science and scientific crowdsourcing in systems biomedicine. [PDF]

Sci Data
Balaur I, Welter D, Rougny A, Inau ET, Mazein A, Ghosh S, Schneider R, Waltemath D, Ostaszewski M, Satagopam V.   +9 more
europepmc   +1 more source

Recap of the 1st Canadian Conference on Open Science and Open Scholarship

Céspedes, Lucía, Beth, Suzanne, Bellen, Simon, Colin-Arce, Alan, Amell, Brittany, Siemens, Ray   +5 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment. [PDF]

Front Toxicol
Teunis M, Luechtefeld T, Hartung T.
europepmc   +1 more source

FAIR data - the photon and neutron communities move together towards open science. [PDF]

IUCrJ
Murphy BM, Götz A, Gutt C, McGuinness C, Rønnow HM, Schneidewind A, Deledda S, Pietsch U.   +7 more
europepmc   +1 more source

Open Science at the generative AI turn: An exploratory analysis of challenges and opportunities. [PDF]

Quant Sci Stud
Hosseini M, Horbach SPJM, Holmes K, Ross-Hellauer T.   +3 more
europepmc   +1 more source

Balancing ethical data sharing and open science for reproducible research in biomedical data science. [PDF]

Cell Rep Med
Lvovs D, Creason AL, Levine SS, Noble M, Mahurkar A, White O, Fertig EJ.   +6 more
europepmc   +1 more source