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Open Science in the Humanities, or: Open Humanities?
Publications, 2019 Open science refers to both the practices and norms of more open and transparent communication and research in scientific disciplines and the discourse on these practices and norms. There is no such discourse dedicated to the humanities.
Marcel Knöchelmann
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Open Software for Open Science
, 2015 This presentation to the Young Alliance Against Cancer workshop in Copenhagen on 23rd May 2015 describes the benefits of open source software and philosophies to scientific research.
openaire +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Open (citizen) science: Prospects and open issues [PDF]
Družboslovne RazpraveThe article discusses the significance of open science, notably the concept of citizen science, within a broader sociopolitical and socio-scientific context.
Frane Adam, Maruša Gorišek
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Open climate science is brave climate science
Environmental Research LettersThe pivotal role of climate science in advancing the UN Sustainable Development Goals underscores the urgent need for ample and open climate data sharing.
Lena M Thöle, Martin Wegmann
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Open Science und Citizen Science als symbiotische Beziehung?
TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2017 In diesem Artikel werden Kernzuschreibungen von Open Science und Citizen Science in der europäischen Wissenschaftspolitik analysiert und zueinander in Beziehung gesetzt.
Katrin Vohland, Claudia Göbel
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Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
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