Results 71 to 80 of about 44,809,382 (241)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

UU Open Science Monitor 2020

, 2022
YODA storage “research-osonderzoek” February 7, 2022 – Dominique Rijshouwer (c.d.n.rijshouwer@uu.nl; openscience@uu.nl) About the project: This data package contains all information relevant to the Project "UU Open Science Monitor 2020 ...
Loek Brinkman (University Medical Center Utrecht), Daniël van Hemert (KU Leuven), Joost de Laat (Utrecht University), Judith de Haan (Utrecht University), Ruth van Veelen (Utrecht University), Sander Thomaes (Utrecht University), Dominique Rijshouwer (Utrecht University)   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The 2020 annual report on the federal progress in implementing open science and its benefits

, 2021
The Government of Canada is committed to making federal science, scientific data, and scientists more accessible. The 2020 Annual Report on the Federal Progress in Implementing Open Science and its Benefits describes the Government of Canada’s progress ...
SBDA Open Science Metrics Working Group, Group, SBDA Open Science Metrics Working   +1 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Open (citizen) science: Prospects and open issues [PDF]

Družboslovne Razprave
The article discusses the significance of open science, notably the concept of citizen science, within a broader sociopolitical and socio-scientific context.
Frane Adam, Maruša Gorišek
doaj  

Open climate science is brave climate science

Environmental Research Letters
The pivotal role of climate science in advancing the UN Sustainable Development Goals underscores the urgent need for ample and open climate data sharing.
Lena M Thöle, Martin Wegmann
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Science For All

Exchanges, 2016
Science is the best method humanity has for understanding the universe and our place in it. However, despite its astonishing achievements, the implementation and communication of science is not without problem.
Liam J. Messin, John C. Meadows
doaj