Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Assessing compliance with smoke-free laws in Purbakhola Rural Municipality, Nepal: A cross-sectional observational study. [PDF]
PLOS Glob Public HealthKc BB, Chand AB, Bam A, Bam TS.
europepmc +1 more source
Hebrew Butcher Workers Union of Greater New York, Local 234, AFL, United Hebrew Trades, Central Trades and Labor Council, Amalgamated Meat Cutters and Butcher Workmen of North America (1936) [PDF]
, 1936 core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Profiling of Antimicrobial Resistance Genes and Genotype-Phenotype Associations in <i>Salmonella</i> spp. Isolated Along the Broiler Production Chain in Karnataka, India. [PDF]
Int J Food SciSohail MN +7 more
europepmc +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, Volume 20, Issue 6, Page 1392-1397, June 2026.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Prevailing Food Safety and Sustainability Practices in Grocerants: A Cross-Sectional Study in Three Countries. [PDF]
Int J Food SciNair SS +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Factors associated with using disposable versus non-disposable electronic cigarettes among adults in the U.S. and Israel: a cross-sectional study with policy implications. [PDF]
Isr J Health Policy ResMulu BA +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source