Results 211 to 220 of about 16,728,413 (378)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

CrisprBuildr: an open-source application for CRISPR-mediated genome engineering in Drosophila melanogaster. [PDF]

G3 (Bethesda)
Horsley N, Sythoff AVB, Delgado M, Liu S, Cabernard C.   +4 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Look inside a Flexible Open-Source Scanning Electrochemical Probe Microscope. [PDF]

ACS Electrochem
McKelvey K, Edwards MA, Kang M, Brunet Cabré M, Jones NB, Unwin PR.   +5 more
europepmc   +1 more source

An open-source FACS automation system for high-throughput cell biology

Diane M. Wiener, Emily Huynh, Ilakkiyan Jeyakumar, Sophie Bax, Samia S. Sama, Joana P. Cabrera, Verina Todorova, Madhuri Vangipuram, Shivanshi Vaid, Fumitaka Otsuka, Yoshitsugu Sakai, Manuel D. Leonetti, Rafael Gómez-Sjöberg   +12 more
openalex   +2 more sources

The PIXIE: A Low-Cost, Open-Source, Multichannel In Situ Fluorometer Applied To Dye-Tracing in Halifax Harbor [PDF]

Kyle Park, Dariia Atamanchuk, Aaron MacNeil, Vincent J. Sieben, Vincent Sieben   +4 more
openalex   +1 more source

OpenSim: Open-Source Software to Create and Analyze Dynamic Simulations of Movement

IEEE Transactions on Biomedical Engineering, 2007
S. Delp, F. Anderson, A. Arnold, P. Loan, Ayman Habib, Chand T. John, Eran Guendelman, D. Thelen   +7 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Open source

Journal of Music, Technology & Education, 2012
Steve Dillon, Mikko Myllykoski, Aapo Rantalainen, S. Alex Ruthmann, Ketil Thorgersen, Lauri Väkevä   +5 more
openaire   +3 more sources

Open-source software for data science. [PDF]

Patterns (N Y)
Hufton AL.
europepmc   +1 more source