Results 261 to 270 of about 16,728,413 (378)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Low-cost open-source camera view splitter (quadscope) for flow diagnostics. [PDF]

HardwareX
Sahoo A, DeBoskey RD, Narayanaswamy V.
europepmc   +1 more source

Open source data logger for low-cost environmental monitoring

, 2014
Edward Baker
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design. [PDF]

CPT Pharmacometrics Syst Pharmacol
Hamadeh A, Pellowe M, Chelle P, Yeung CHT, Otalvaro J, Yamada W, Bartroff J, Kryshchenko A, Dallmann A, Solodenko J, Lippert J, Tsakalozou E, Neely M, Edginton A.   +13 more
europepmc   +1 more source

Automated Target Profiling: Leveraging Artificial Intelligence for Open-Source Intelligence Collection

R. Soler, Maurice Dawson, Marc Colina
openalex   +1 more source

Using Free/Libre and Open Source Software in the Geological Sciences

, 2017
Dieter Mader, Bettina Schenk
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Open-source cell culture automation system with integrated cell counting for passaging microplate cultures. [PDF]

PNAS Nexus
Courville G, Vaid S, Toruño A, Lebel P, Cabrera JP, Raghavan P, Jacobsen A, Bell GRR, Leonetti MD, Gómez-Sjöberg R.   +9 more
europepmc   +1 more source

Development of a surgical guide using open-source software for a dental implant placement

Dita Ayu Mayasari, Menik Dwi Kurniatie, Wisnu Adi Prasetyanto, Shafa Salsa Fadhila, Budi Wicaksono, Reza Dony Hendrawan   +5 more
openalex   +2 more sources