Results 261 to 270 of about 7,376,780 (336)

An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design. [PDF]

CPT Pharmacometrics Syst Pharmacol
Hamadeh A, Pellowe M, Chelle P, Yeung CHT, Otalvaro J, Yamada W, Bartroff J, Kryshchenko A, Dallmann A, Solodenko J, Lippert J, Tsakalozou E, Neely M, Edginton A.   +13 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Open-source cell culture automation system with integrated cell counting for passaging microplate cultures. [PDF]

PNAS Nexus
Courville G, Vaid S, Toruño A, Lebel P, Cabrera JP, Raghavan P, Jacobsen A, Bell GRR, Leonetti MD, Gómez-Sjöberg R.   +9 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Open-source sub-nanometer stabilization system for super-resolution fluorescence microscopy. [PDF]

Light Sci Appl
Edorna F, Choque FD, Ferrari G, Masullo LA, Zdańkowski P, Acuna GP, Tinnefeld P, Szalai AM, Lopez LF, Zelcer A, Stefani FD.   +10 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

mAIcrobe: an open-source framework for high-throughput bacterial image analysis

Brito AD, Alwardt D, Mariz BdP, Filipe SR, Pinho MG, Saraiva BM, Henriques R.   +6 more
europepmc   +1 more source

Servicing open-source large language models for oncology. [PDF]

Oncologist
Ray PP.
europepmc   +1 more source

PyCubed Mini: An Open-Source, Computational Platform for Education and Research in the Pocketqube Form Factor

, 2020
Andrew Gatherer, Max Holiday, Zachary Manchester   +2 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source