Results 21 to 30 of about 7,376,780 (336)

QSAR-based models for designing quinazoline/imidazothiazoles/pyrazolopyrimidines based inhibitors against wild and mutant EGFR. [PDF]

PLoS ONE, 2014
Overexpression of EGFR is responsible for causing a number of cancers, including lung cancer as it activates various downstream signaling pathways. Thus, it is important to control EGFR function in order to treat the cancer patients.
Jagat Singh Chauhan, Sandeep Kumar Dhanda, Deepak Singla, Open Source Drug Discovery Consortium, Subhash M Agarwal, Gajendra P S Raghava   +5 more
doaj   +1 more source

Resources, challenges and way forward in rare mitochondrial diseases research [v2; ref status: indexed, http://f1000r.es/5r6]

F1000Research, 2015
Over 300 million people are affected by about 7000 rare diseases globally. There are tremendous resource limitations and challenges in driving research and drug development for rare diseases.
Neeraj Kumar Rajput, Vipin Singh, Anshu Bhardwaj   +2 more
doaj   +1 more source

ESPEE: Event-Based Sensor Pose Estimation Using an Extended Kalman Filter

Sensors, 2021
Event-based vision sensors show great promise for use in embedded applications requiring low-latency passive sensing at a low computational cost. In this paper, we present an event-based algorithm that relies on an Extended Kalman Filter for 6-Degree of ...
Fabien Colonnier, Luca Della Vedova, Garrick Orchard   +2 more
doaj   +1 more source

Open Source for Open Source License Compliance

, 2019
Today, many software systems are of a level of complexity that no single company can implement modern solutions alone. Thus many companies engage in the open source software (OSS) ecosystem to keep the development costs manageable. But the usage of third-party components (both OSS and commercial) also mandates the need of a license compliance process ...
Fendt, Oliver, Jaeger, Michael
openaire   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Measuring and mitigating debugging effectiveness decay in code language models

Scientific Reports
The effectiveness of AI debugging follows a predictable exponential decay pattern; most models lose 60-80% of their debugging capability within just 2-3 attempts, despite iterative debugging being a critical capability for practical code generation ...
Muntasir Adnan, Carlos C. N. Kuhn
doaj   +1 more source

Resources, challenges and way forward in rare mitochondrial diseases research [v1; ref status: indexed, http://f1000r.es/54x]

F1000Research, 2015
Over 300 million people are affected by about 7000 rare diseases globally. There are tremendous resource limitations and challenges in driving research and drug development for rare diseases.
Anshu Bhardwaj, Neeraj Kumar Rajput, Vipin Singh   +2 more
doaj   +1 more source

Usability and open source software. [PDF]

, 2002
Open source communities have successfully developed many pieces of software although most computer users only use proprietary applications. The usability of open source software is often regarded as one reason for this limited distribution. In this paper
Nichols, David M., Twidale, Michael B.
core   +1 more source

Why Modern Open Source Projects Fail

, 2017
Open source is experiencing a renaissance period, due to the appearance of modern platforms and workflows for developing and maintaining public code. As a result, developers are creating open source software at speeds never seen before.
Androutsellis-Theotokis Stephanos, Humphrey Watts S., Lavallée Mathieu, Lehman Meir M., Standish Group, Tourani Parastou   +5 more
core   +1 more source