Results 21 to 30 of about 7,872,338 (287)

QSAR-based models for designing quinazoline/imidazothiazoles/pyrazolopyrimidines based inhibitors against wild and mutant EGFR. [PDF]

PLoS ONE, 2014
Overexpression of EGFR is responsible for causing a number of cancers, including lung cancer as it activates various downstream signaling pathways. Thus, it is important to control EGFR function in order to treat the cancer patients.
Jagat Singh Chauhan, Sandeep Kumar Dhanda, Deepak Singla, Open Source Drug Discovery Consortium, Subhash M Agarwal, Gajendra P S Raghava   +5 more
doaj   +1 more source

Resources, challenges and way forward in rare mitochondrial diseases research [v2; ref status: indexed, http://f1000r.es/5r6]

F1000Research, 2015
Over 300 million people are affected by about 7000 rare diseases globally. There are tremendous resource limitations and challenges in driving research and drug development for rare diseases.
Neeraj Kumar Rajput, Vipin Singh, Anshu Bhardwaj   +2 more
doaj   +1 more source

ESPEE: Event-Based Sensor Pose Estimation Using an Extended Kalman Filter

Sensors, 2021
Event-based vision sensors show great promise for use in embedded applications requiring low-latency passive sensing at a low computational cost. In this paper, we present an event-based algorithm that relies on an Extended Kalman Filter for 6-Degree of ...
Fabien Colonnier, Luca Della Vedova, Garrick Orchard   +2 more
doaj   +1 more source

Open Source for Open Source License Compliance

, 2019
Today, many software systems are of a level of complexity that no single company can implement modern solutions alone. Thus many companies engage in the open source software (OSS) ecosystem to keep the development costs manageable. But the usage of third-party components (both OSS and commercial) also mandates the need of a license compliance process ...
Fendt, Oliver, Jaeger, Michael
openaire   +1 more source

Why Modern Open Source Projects Fail

, 2017
Open source is experiencing a renaissance period, due to the appearance of modern platforms and workflows for developing and maintaining public code. As a result, developers are creating open source software at speeds never seen before.
Androutsellis-Theotokis Stephanos, Humphrey Watts S., Lavallée Mathieu, Lehman Meir M., Standish Group, Tourani Parastou   +5 more
core   +1 more source

Exploring usability discussions in open source development [PDF]

, 2005
The public nature of discussion in open source projects provides a valuable resource for understanding the mechanisms of open source software development. In this paper we explore how open source projects address issues of usability.
Nichols, David M., Twidale, Michael B.
core   +2 more sources

Stressful Events Reported by Childhood Cancer Survivors and Community Controls From the St. Jude Lifetime (SJLIFE) Cohort: A Mixed Method Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware, Colter K. Clayton, Fang Wang, Sedigheh Mirzaei, Kyla Shelton, Tara M. Brinkman, Victoria Willard, Katianne M. Howard Sharp, Kevin Krull, Lindsay F. Schwartz, Melissa M. Hudson, Gregory T. Armstrong, Kirsten K. Ness, Rachel T. Webster   +13 more
wiley   +1 more source

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Measuring and mitigating debugging effectiveness decay in code language models

Scientific Reports
The effectiveness of AI debugging follows a predictable exponential decay pattern; most models lose 60-80% of their debugging capability within just 2-3 attempts, despite iterative debugging being a critical capability for practical code generation ...
Muntasir Adnan, Carlos C. N. Kuhn
doaj   +1 more source

Resources, challenges and way forward in rare mitochondrial diseases research [v1; ref status: indexed, http://f1000r.es/54x]

F1000Research, 2015
Over 300 million people are affected by about 7000 rare diseases globally. There are tremendous resource limitations and challenges in driving research and drug development for rare diseases.
Anshu Bhardwaj, Neeraj Kumar Rajput, Vipin Singh   +2 more
doaj   +1 more source