Results 291 to 300 of about 16,728,413 (378)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Robust, Open-Source and Automation-Friendly DNA Extraction Protocol for Hologenomic Research. [PDF]

Mol Ecol Resour
Lauritsen JG, Carøe C, Gaun N, Martin-Bideguren G, Leonard A, Eisenhofer R, Odriozola I, Gilbert MTP, Aizpurua O, Alberdi A, Pietroni C.   +10 more
europepmc   +1 more source

An Open-Source Web Platform for Sentinel-2 Multispectral Analysis in Smallholder Agriculture: Design, Implementation and Validation

João L. S. Melo, Luís G. O. C. da Silva, João V. P. C. B. Carvalho, Lauan M. R. Alves, Vinicius H. A. Andrade, Lucas B. Pereira   +5 more
openalex   +2 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

CCKit: An open-source toolkit for cache coherent accelerators

Ramdas, Abishek, Cock, David Alan, Giardino, Michael Joseph, Korolija, Dario, Ruzhanskaia, Anastasiia, Schwyn, Daniel, Turowski, Adam, Alonso, Gustavo, Roscoe, Timothy   +8 more
openalex   +2 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Benchmarking proprietary and open-source language and vision-language models for gastroenterology clinical reasoning. [PDF]

NPJ Digit Med
Safavi-Naini SAA, Ali S, Shahab O, Shahhoseini Z, Savage T, Rafiee S, Samaan JS, Al Shabeeb R, Ladak F, Yang JO, Echavarria J, Babar S, Shaukat A, Margolis S, Tatonetti NP, Nadkarni G, El Kurdi B, Soroush A.   +17 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Talk2Biomodels: AI agent-based open-source LLM initiative for kinetic biological models. [PDF]

BMC Bioinformatics
Wehling L, Singh G, Mulyadi AW, Sreenath RH, Hermjakob H, Nguyen TVN, Rückle T, Mosa MH, Cordes H, Andreani T, Klabunde T, Malik Sheriff RS, McCloskey D.   +12 more
europepmc   +1 more source

Analyzing the Usage of Open Source Products for Soa

, 2012
Sajid Ali
openalex   +1 more source