Results 111 to 120 of about 22,332,829 (306)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

A Taste for Trips out of Town: Urban Sprawl and Access to Open Space [PDF]

open access: yes
Residential development at the urban fringe raises the cost of trips to open space. We derive a simple expression for the tax that internalizes this effect of sprawl in a monocentric city andapply it using survey data on recreational activity.
Wouter Vermeulen, Jan Rouwendal
core  

Reducing the prosthesis modulus by inclusion of an open space lattice improves osteogenic response in a sheep model of extraarticular defect. [PDF]

open access: yesFront Bioeng Biotechnol, 2023
Sanaei R   +12 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

The Trade-off between Private Lots and Public Open Space in Subdivisions at the Urban-Rural Fringe [PDF]

open access: yes
In many communities on the urban–rural fringe, subdivisions are subject to “clustering” rules, in which houses must be located on a portion of the total land area and the remainder of the land is left as open space.
McConnell, Virginia D.   +2 more
core  

Compact city or dispersed form reality: Banja Luka case study

open access: yesGeodetski Vestnik
According to recent urban theory and research, many cities have transformed from formations with recognisable centres, periphery and precise edges to large, dispersed tissues that penetrate deep into their hinterland.
Nevena Novaković   +2 more
doaj   +1 more source

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