Results 51 to 60 of about 20,809,034 (299)

Effect of Housing Layout and Open Space Morphology on Residential Environments–Applying New Density Indices for Evaluation of Residential Areas Case Study: Tehran, Iran

Journal of Asian Architecture and Building Engineering, 2018
Over time, urban developments with increased densities have led to a decrease in private open space with a lack of public open space. Residential open spaces are missing in housing legislations as they are estimated based on floor area ratio and building
Sepideh Payami Azad, Ryohei Morinaga, Hideki Kobayashi   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A primordial noble gas component discovered in the Ryugu asteroid and its implications

Nature Communications
Ryugu is the C-type asteroid from which material was brought to Earth by the Hayabusa2 mission. A number of individual grains and fine-grained samples analysed so far for noble gases have indicated that solar wind and planetary (known as P1) noble gases ...
Alexander B. Verchovsky, Feargus A. J. Abernethy, Mahesh Anand, Ian A. Franchi, Monica M. Grady, Richard C. Greenwood, Simeon J. Barber, Martin Suttle, Motoo Ito, Naotaka Tomioka, Masayuki Uesugi, Akira Yamaguchi, Makoto Kimura, Naoya Imae, Naoki Shirai, Takuji Ohigashi, Ming-Chang Liu, Kentaro Uesugi, Aiko Nakato, Kasumi Yogata, Hayato Yuzawa, Yuzuru Karouji, Satoru Nakazawa, Tatsuaki Okada, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Akiko Miyazaki, Masahiro Nishimura, Toru Yada, Masanao Abe, Tomohiro Usui, Sen-ichiro Watanabe, Yuichi Tsuda, Consortium Phase2 curation team Kochi   +35 more
doaj   +1 more source

Geology of the Borealis quadrangle (H01), Mercury

Journal of Maps
We present the first complete geological map of the Borealis quadrangle (H01), Mercury’s north polar region. H01 spans latitudes 65°N to 90°N and longitudes 0°–360°, covering an area just over 3.5 million km2, approximately 4.7% of the planet’s surface ...
Benjamin Man, David A. Rothery, Sébastien Besse, Valentina Galluzzi, Jack Wright, Paolo Mancinelli, Laura Guzzetta   +6 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Strategies to Improve Sustainability in Urban Landscape, Literature Review

Journal of Landscape Ecology, 2016
Decreasing green spaces is a significant concern in today’s compact cities while they provide various dimensions of sustainability; therefore, sustainable development has become the key idea to solve a series of environmental, economic and social ...
Rakhshandehroo Mehdi, Mohd Yusof Mohd Johari, Arabi Roozbeh, Jahandarfard Rasul   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Grottoes, VA: Conceptual Open Space Master Plan and Entrance Design

, 2022
The Community Design Assistance Center (CDAC) worked with the town of Grottoes to create entryway designs for the primary entries to town as well as Sixth Street, which serves as the town’s “Main Street.” CDAC also prepared an open space master plan ...
Gilboy, Elizabeth, Watson, Kim, Jessup, Jennifer, Brown, Julia   +3 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source