Results 91 to 100 of about 1,318,208 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Perception of open urban space – Bevk square in Nova Gorica [PDF]

Urbani Izziv, 1997
In research on perception of open urban space, psychological and structural aspects are important, as well as social use. Social use however is most important, because open urban space and its green surfaces satisfies needs of an urban population.
Nataša Bratina
doaj  

Hydrogen cyanide and carboxyhemoglobin assessment in an open space fire-related fatality. [PDF]

J Forensic Sci, 2021
Tabian D, Bulgaru Iliescu D, Iov T, Barna B, Toma SI, Drochioiu G.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

History of Open Space and Physical Activities of China’s Danwei Neighborhood: The Case Study of Community Hua

Buildings
The danwei community emerged as a basic socio-spatial unit in China’s urban landscape, primarily constructed in the mid-20th century. Today, amid population aging and the deterioration of service facilities supporting health environment, the mental and ...
Hanxiao Heng, Xuan He, Nina Mo
doaj   +1 more source

To Create a Safe and Healthy Place for Children: The Associations of Green Open Space Characteristics With Children's Use. [PDF]

Front Public Health, 2021
Ma M, Adeney M, Chen W, Deng D, Tan S.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vivo, in vitro and in silico: an open space for the development of microbe-based applications of synthetic biology. [PDF]

Microb Biotechnol, 2022
Danchin A.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Sunlight as a common good. A comparative study of the overshadowing of public spaces adjacent to contemporary multifamily housing developments based on the Wrocław example

Technical Transactions
Sunlight plays a crucial role in everyday life. Contemporary regulations and research emphasize solar access to buildings, with more limited consideration to open spaces (OSs).
Kazanecka-Olejnik Lea
doaj   +1 more source