Results 61 to 70 of about 20,792,994 (299)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A primordial noble gas component discovered in the Ryugu asteroid and its implications

Nature Communications
Ryugu is the C-type asteroid from which material was brought to Earth by the Hayabusa2 mission. A number of individual grains and fine-grained samples analysed so far for noble gases have indicated that solar wind and planetary (known as P1) noble gases ...
Alexander B. Verchovsky, Feargus A. J. Abernethy, Mahesh Anand, Ian A. Franchi, Monica M. Grady, Richard C. Greenwood, Simeon J. Barber, Martin Suttle, Motoo Ito, Naotaka Tomioka, Masayuki Uesugi, Akira Yamaguchi, Makoto Kimura, Naoya Imae, Naoki Shirai, Takuji Ohigashi, Ming-Chang Liu, Kentaro Uesugi, Aiko Nakato, Kasumi Yogata, Hayato Yuzawa, Yuzuru Karouji, Satoru Nakazawa, Tatsuaki Okada, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Akiko Miyazaki, Masahiro Nishimura, Toru Yada, Masanao Abe, Tomohiro Usui, Sen-ichiro Watanabe, Yuichi Tsuda, Consortium Phase2 curation team Kochi   +35 more
doaj   +1 more source

Geology of the Borealis quadrangle (H01), Mercury

Journal of Maps
We present the first complete geological map of the Borealis quadrangle (H01), Mercury’s north polar region. H01 spans latitudes 65°N to 90°N and longitudes 0°–360°, covering an area just over 3.5 million km2, approximately 4.7% of the planet’s surface ...
Benjamin Man, David A. Rothery, Sébastien Besse, Valentina Galluzzi, Jack Wright, Paolo Mancinelli, Laura Guzzetta   +6 more
doaj   +1 more source

Effect of Housing Layout and Open Space Morphology on Residential Environments–Applying New Density Indices for Evaluation of Residential Areas Case Study: Tehran, Iran

Journal of Asian Architecture and Building Engineering, 2018
Over time, urban developments with increased densities have led to a decrease in private open space with a lack of public open space. Residential open spaces are missing in housing legislations as they are estimated based on floor area ratio and building
Sepideh Payami Azad, Ryohei Morinaga, Hideki Kobayashi   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Grottoes, VA: Conceptual Open Space Master Plan and Entrance Design

, 2022
The Community Design Assistance Center (CDAC) worked with the town of Grottoes to create entryway designs for the primary entries to town as well as Sixth Street, which serves as the town’s “Main Street.” CDAC also prepared an open space master plan ...
Gilboy, Elizabeth, Watson, Kim, Jessup, Jennifer, Brown, Julia   +3 more
core  

Strategies to Improve Sustainability in Urban Landscape, Literature Review

Journal of Landscape Ecology, 2016
Decreasing green spaces is a significant concern in today’s compact cities while they provide various dimensions of sustainability; therefore, sustainable development has become the key idea to solve a series of environmental, economic and social ...
Rakhshandehroo Mehdi, Mohd Yusof Mohd Johari, Arabi Roozbeh, Jahandarfard Rasul   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source