Results 71 to 80 of about 1,465,825 (259)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A framework for assessing grey multitasking effectiveness of satellite communication constellation
Scientific ReportsTask effectiveness, defined as the likelihood that a system will complete specific tasks under predefined conditions and within a given timeframe, is a crucial indicator of the system’s overall performance and fundamental quality attributes.
Ruirui Shao +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
ISPRS International Journal of Geo-InformationDementia has become a profound public health problem due to the number of patients increasing every year. Previous studies have reported that environmental factors, including greenness, may influence the development and progression of dementia.
Wulan Salle Karurung +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Itinéraires rituels et évolution de l’espace public à Téhéran (1831-1941)
Géographie et Cultures, 2018 Traditional religious rites obey rules and impose discipline on members of the community at public gatherings. This article aims to demonstrate the influence of ambulatory ceremonies on the physical transformation of Tehran (Iran) about a century (1831 ...
Guy Baudelle +4 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
ISPRS International Journal of Geo-Information, 2017 This study proposes an innovative integrated method for evaluating the evacuation and rescue capabilities of open spaces through a case study in Wuhan, China.
Jie Gong +4 more
doaj +1 more source