Results 41 to 50 of about 22,332,829 (306)

A framework for designing the open spaces in the children’s educational centers based on the (Seven Cs) with emphasis on pProve the learning [PDF]

Fanāvarī-i āmūzish, 2016
The main purpose of this study was to identify the effectiveness factors in the design of open space in educational centers for children and its relationship to learning. Because learning and convey the meaning is an inseparable part in every educational
M. Khakzand, S. Babaei
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Study of literary works in the aspect of artistic time and space continuum (on the example of literature lessons)

Вестник Майкопского государственного технологического университета, 2023
The relevance of the article is due to the lack of attention to the issues of studying literary works through the prism of the concepts of artistic time and space in Literature lessons at school.
Gulnaz Nurfatovna Mukharlyamova, Dilaria Maratovna Abdullina   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Economic Impact of Labeled Regional Products: The Experience of the UNESCO Biosphere Reserve Entlebuch

Mountain Research and Development, 2017
Protected area management bodies are increasingly required to address economic development alongside the original goal of conservation. This is especially true for United Nations Educational, Scientific and Cultural Organization (UNESCO) biosphere ...
Florian Knaus, Lea Ketterer Bonnelame, Dominik Siegrist   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microclimate governs the morphology of sediment flows on Mars

Communications Earth & Environment
Landforms created by flowing water with sediment have left deposits on the surface of Mars, allowing study of the ancient environment. These features could provide constraints on surface water activity and past habitability.
Jacob B. Adler, Frances Rivera-Hernández, Sharissa Thompson, Petr Brož, Matthew E. Sylvest, Zoe S. Emerland, Manish Patel, Mark Fox-Powell   +7 more
doaj   +1 more source