Results 61 to 70 of about 22,332,829 (306)

Effect of Housing Layout and Open Space Morphology on Residential Environments–Applying New Density Indices for Evaluation of Residential Areas Case Study: Tehran, Iran

Journal of Asian Architecture and Building Engineering, 2018
Over time, urban developments with increased densities have led to a decrease in private open space with a lack of public open space. Residential open spaces are missing in housing legislations as they are estimated based on floor area ratio and building
Sepideh Payami Azad, Ryohei Morinaga, Hideki Kobayashi   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A primordial noble gas component discovered in the Ryugu asteroid and its implications

Nature Communications
Ryugu is the C-type asteroid from which material was brought to Earth by the Hayabusa2 mission. A number of individual grains and fine-grained samples analysed so far for noble gases have indicated that solar wind and planetary (known as P1) noble gases ...
Alexander B. Verchovsky, Feargus A. J. Abernethy, Mahesh Anand, Ian A. Franchi, Monica M. Grady, Richard C. Greenwood, Simeon J. Barber, Martin Suttle, Motoo Ito, Naotaka Tomioka, Masayuki Uesugi, Akira Yamaguchi, Makoto Kimura, Naoya Imae, Naoki Shirai, Takuji Ohigashi, Ming-Chang Liu, Kentaro Uesugi, Aiko Nakato, Kasumi Yogata, Hayato Yuzawa, Yuzuru Karouji, Satoru Nakazawa, Tatsuaki Okada, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Akiko Miyazaki, Masahiro Nishimura, Toru Yada, Masanao Abe, Tomohiro Usui, Sen-ichiro Watanabe, Yuichi Tsuda, Consortium Phase2 curation team Kochi   +35 more
doaj   +1 more source

Geology of the Borealis quadrangle (H01), Mercury

Journal of Maps
We present the first complete geological map of the Borealis quadrangle (H01), Mercury’s north polar region. H01 spans latitudes 65°N to 90°N and longitudes 0°–360°, covering an area just over 3.5 million km2, approximately 4.7% of the planet’s surface ...
Benjamin Man, David A. Rothery, Sébastien Besse, Valentina Galluzzi, Jack Wright, Paolo Mancinelli, Laura Guzzetta   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Detection Of Green Open Space Using Combination Index Of Landsat 8 Data (Case Study: DKI Jakarta) [PDF]

, 2016
Spatial information about the availability and presence of green open space in urban areas to be up to date and transparent was a necessity. This study explained the technique to get the green open spaces of spatial information quickly using an index ...
Sayidah Sulma, Jalu Tejo Nugroho, Zubaidah, Any, Sulma, Sayidah, Haryani, Nanik Suryo, Hana Listi Fitriana, Any Zubaidah, Nanik Suryo Haryani, Nugroho, Jalu Tejo, Fitriana, Hana Listi   +9 more
core   +1 more source

Strategies to Improve Sustainability in Urban Landscape, Literature Review

Journal of Landscape Ecology, 2016
Decreasing green spaces is a significant concern in today’s compact cities while they provide various dimensions of sustainability; therefore, sustainable development has become the key idea to solve a series of environmental, economic and social ...
Rakhshandehroo Mehdi, Mohd Yusof Mohd Johari, Arabi Roozbeh, Jahandarfard Rasul   +3 more
doaj   +1 more source

Underlying relational dimensions of flow transitions along ring roads and their impacts on the typo-morphology of open spaces: two cases from Nordic countries

Urban, Planning and Transport Research, 2021
This study explores the roles and functions of urban voids and their relationship with the built forms alongside ring roads. This investigation sheds light on the typo-morphology of open spaces in regard to the flow transitions (in substance, intensity ...
Alia’a Amr
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source