Results 151 to 160 of about 344,290 (331)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Census of Blue Straggler Stars in Distant Open Clusters and Maximum Fractional Mass Excess of Open Cluster Blue Straggler Stars

The Astronomical Journal
We identified blue straggler stars (BSSs) in 53 open clusters utilizing data from Gaia DR3. Most of these clusters are situated in the outer regions of the Galactic disk, encompassing structures such as the warp and the Outer arm.
Qian Cui, Zhihong He, Shunhong Deng, Liming Peng, Chunyan Li, Yangping Luo, Kun Wang   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Census of Pulsars in Possible Association with Galactic Open Clusters

The Astrophysical Journal Letters
Among the ∼4000 known pulsars in our Galaxy, ≲10% are found in globular clusters, but none has been confirmed in any open clusters yet, although they outnumber globular clusters by about 20 times.
Lu Zhou, Zhi-Qiang You, Lu Li, Xiao-Jin Liu, Xing-Jiang Zhu, Zong-Hong Zhu   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Calibrating the Color–Magnitude Relation of M Giants by Using Open Clusters

The Astrophysical Journal Supplement Series
M giants, with their distinctive properties such as high luminosity, serve as excellent indicators for mapping the structure of the Milky Way. The distance to distant M giants can be determined by using the color–magnitude relation (CMR), which is ...
X. Y. Tang, C. J. Hao, J. Li, Z. Z. Yan, Y. Xu, J. Zhong, Z. H. Lin, Y. J. Li, D. J. Liu, L. F. Ding, X. F. Long   +10 more
doaj   +1 more source

Young open clusters in the Galactic star forming region NGC 6357 [PDF]

, 2014
F. Massi, A. Giannetti, E. Di Carlo, J. Brand, M. T. Beltrán, G. Marconi   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Comprehensive Analysis of NGC 6134: Structure, Dynamics, and Blue Straggler Star Candidates

The Astrophysical Journal Supplement Series
Open clusters play a critical role in the study of both stellar and Galactic evolution. We present a comprehensive analysis of the open cluster NGC 6134 using Gaia DR3 astrometric and photometric data, supplemented with multiwavelength observations from ...
Dexin Zeng, Ying Mei, Huanbin Chi, Hui Deng, Feng Wang   +4 more
doaj   +1 more source

The very rich massive post-main-sequence star population of the open cluster Westerlund 1 [PDF]

, 2003
I. Negueruela, J. S. Clark
openalex   +1 more source