Results 171 to 180 of about 134,869 (325)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

BINARIES IN OPEN STAR CLUSTERS: PHOTOMETRIC APPROACH WITH APPLICATION TO THE HYADES [PDF]

, 2004
A. El-Bassuny Alawy, B. Korany, A. A. Haroon, H. A. Ismail, M. A. Sharaf   +4 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

The Present-day Mass Function of Star Clusters in the Solar Neighborhood

The Astrophysical Journal
This work analyzes the present-day mass function (PDMF) of 93 star clusters utilizing Gaia Data Release 3 data, with membership determined by the StarGo machine-learning algorithm.
Xiaoying Pang, Siqi Liao, Jiadong Li, Zhiqiang Yan, Mingjie Jian, M. B. N. Kouwenhoven, Shih-Yun Tang, Yifan Wang   +7 more
doaj   +1 more source

NGC 146: a young open cluster with a Herbig Be star and intermediate mass pre-main sequence stars [PDF]

, 2005
Annapurni Subramaniam, D. K. Sahu, R. Sagar, P. Vijitha   +3 more
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

An analytical description of the disruption of star clusters in tidal fields with an application to Galactic open clusters [PDF]

, 2005
H. J. G. L. M. Lamers, Mark Gieles, N. Bastian, Holger Baumgardt, N. V. Kharchenko, Simon Portegies Zwart   +5 more
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Using Detailed Single-star and Binary-evolution Models to Probe the Large Observed Luminosity Spread of Red Supergiants in Young Open Star Clusters

The Astrophysical Journal Letters
Red supergiants (RSGs) represent a late evolutionary stage of massive stars. Recent observations reveal that the observed luminosity range of RSGs in young open clusters is wider than expected from single-star evolution models.
Chen Wang, Lee Patrick, Abel Schootemeijer, Selma E. de Mink, Norbert Langer, Nikolay Britavskiy, Xiao-Tian Xu, Julia Bodensteiner, Eva Laplace, Ruggero Valli, Alejandro Vigna-Gómez, Jakub Klencki, Stephen Justham, Cole Johnston, Jing-ze Ma   +14 more
doaj   +1 more source

Observations of 14 young open star clusters with the HEGRA system of Cherenkov telescopes [PDF]

, 2006
F. Aharonian, A. G. Akhperjanian, M. Beilicke, K. Bernlöhr, H. Börst, H. Bojahr, O. Bolz, T. Coarasa, J. L. Contreras, J. Cortina, S. Denninghoff, M. V. Fonseca, M. Girma, N. Götting, G. Heinzelmann, G. Hermann, Andréas Heusler, W. Hofmann, D. Horns, I. Jung, R. Kankanyan, M. Kestel, A. Konopelko, H. Kornmeyer, D. Kranich, H. Lampeitl, Marcos López, E. Lorenz, F. Lucarelli, O. Mang, H. Meyer, R. Mirzoyan, A. Moralejo, E. de Oña Wilhelmi, M. Panter, A. Plyasheshnikov, G. Pühlhofer, R. de los Reyes, W. Rhode, J. Ripken, Gavin Rowell, V. Sahakian, M. Samorski, M. Schilling, M. Siems, D. Sobzynska, W. Stamm, M. Tluczykont, V. Vitale, H. J. Völk, C. A. Wiedner, W. Wittek   +51 more
openalex   +1 more source