Results 171 to 180 of about 239,741 (340)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Calibrating the Color–Magnitude Relation of M Giants by Using Open Clusters

The Astrophysical Journal Supplement Series
M giants, with their distinctive properties such as high luminosity, serve as excellent indicators for mapping the structure of the Milky Way. The distance to distant M giants can be determined by using the color–magnitude relation (CMR), which is ...
X. Y. Tang, C. J. Hao, J. Li, Z. Z. Yan, Y. Xu, J. Zhong, Z. H. Lin, Y. J. Li, D. J. Liu, L. F. Ding, X. F. Long   +10 more
doaj   +1 more source

Empirical Isochrone Construction Within Open Star Cluster Investigation [PDF]

V. O. Mikhnevich, Anastasiia Plotnikova
openalex   +1 more source

Massive open star clusters using the VVV survey [PDF]

, 2012
André-Nicolas Chené, J. Borissova, J. R. A. Clarke, C. Bonatto, D. Majaess, C. Moni Bidin, S. E. Sale, F. Mauro, R. Kurtev, G. Baume, Douglas Ferreira Carlos, V. D. Ivanov, D. Geisler, M. Catelan, D. Minniti, P. W. Lucas, Richard de Grijs, M. S. N. Kumar   +17 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Comprehensive Analysis of NGC 6134: Structure, Dynamics, and Blue Straggler Star Candidates

The Astrophysical Journal Supplement Series
Open clusters play a critical role in the study of both stellar and Galactic evolution. We present a comprehensive analysis of the open cluster NGC 6134 using Gaia DR3 astrometric and photometric data, supplemented with multiwavelength observations from ...
Dexin Zeng, Ying Mei, Huanbin Chi, Hui Deng, Feng Wang   +4 more
doaj   +1 more source

Long-term spectral variability of the O4If⁺ star HD 15570 in the open cluster IC 1805 [PDF]

, 2003
V. F. Polcaro, Roberto Viotti, L. Norci, Corinne Rossi, P. Eenens, L. J. Corral   +5 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Investigating 56 High Galactic Latitude Open Cluster Candidates in Gaia DR3

The Astrophysical Journal
Using Gaia DR3 data, we revisit 56 high Galactic latitude (∣ b ∣ ≥ 30°) open cluster (OC) candidates with poor shapes of color–magnitude diagrams (CMDs), including unclear and paired main sequences (MSs).
You Wu, Jing Chen, Su Zhang, Xingyin Wei, Feilong He, Yunbo Zhao, Xuran He   +6 more
doaj   +1 more source