Results 171 to 180 of about 240,639 (335)

Census of Blue Straggler Stars in Distant Open Clusters and Maximum Fractional Mass Excess of Open Cluster Blue Straggler Stars

open access: yesThe Astronomical Journal
We identified blue straggler stars (BSSs) in 53 open clusters utilizing data from Gaia DR3. Most of these clusters are situated in the outer regions of the Galactic disk, encompassing structures such as the warp and the Outer arm.
Qian Cui   +6 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

A Census of Pulsars in Possible Association with Galactic Open Clusters

open access: yesThe Astrophysical Journal Letters
Among the ∼4000 known pulsars in our Galaxy, ≲10% are found in globular clusters, but none has been confirmed in any open clusters yet, although they outnumber globular clusters by about 20 times.
Lu Zhou   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Calibrating the Color–Magnitude Relation of M Giants by Using Open Clusters

open access: yesThe Astrophysical Journal Supplement Series
M giants, with their distinctive properties such as high luminosity, serve as excellent indicators for mapping the structure of the Milky Way. The distance to distant M giants can be determined by using the color–magnitude relation (CMR), which is ...
X. Y. Tang   +10 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Comprehensive Analysis of NGC 6134: Structure, Dynamics, and Blue Straggler Star Candidates

open access: yesThe Astrophysical Journal Supplement Series
Open clusters play a critical role in the study of both stellar and Galactic evolution. We present a comprehensive analysis of the open cluster NGC 6134 using Gaia DR3 astrometric and photometric data, supplemented with multiwavelength observations from ...
Dexin Zeng   +4 more
doaj   +1 more source

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