Results 211 to 220 of about 134,869 (325)

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Super-resolution microscopy reveals glioma cell footprints and exosome deposits. [PDF]

Cell Adh Migr
Petrini S, Eghiaian F, Apollonio V, Pericoli G, Vinci M.   +4 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Pre-main-sequence stars in the young open cluster NGC 1893 II. Evidence for triggered massive star formation [PDF]

, 2007
I. Negueruela, A. Marco, G. L. Israel, Guillermo Bernabeu   +3 more
openalex   +1 more source

Fundamentals of Stellar Parameters Estimation through CMD of Star Clusters: Open (NGC2360) and Globular (NGC 5272)

, 2022
Kanwar Preet Kaur, Pankaj S. Joshi
openalex   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Konnektor: A Framework for Using Graph Theory to Plan Networks for Free Energy Calculations. [PDF]

J Chem Inf Model
Ries B, Gowers RJ, Baumann HM, Swenson DWH, Henry MM, Eastwood JRB, Alibay I, Mobley D.   +7 more
europepmc   +1 more source

The role of radial migration in open cluster and field star populations with Gaia DR3

, 2023
C. Viscasillas Vázquez, L. Magrini, L. Spina, G. Tautvaišienė, M. Van der Swaelmen, S. Randich, G. G. Sacco   +6 more
openalex   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Fast analysis of Spatial Transcriptomics (FaST): an ultra lightweight and fast pipeline for the analysis of high resolution spatial transcriptomics. [PDF]

NAR Genom Bioinform
Fulci V.
europepmc   +1 more source