Results 111 to 120 of about 1,821,718 (352)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Endovascular Treatment versus Open Surgical Repair for Isolated Iliac Artery Aneurysms
Vascular Specialist InternationalPurpose: Endovascular treatment (EVT) has been shown to be effective and safe for isolated iliac artery aneurysms (IAAs). However, concerns remain regarding the lack of consideration to recent advances in perioperative care and surgical techniques, as ...
Eol Choi, Tae Won Kwon
doaj +1 more source
Laparoscopic versus conventional open surgery in T4 rectal cancer: A case–control study
Journal of Minimal Access Surgery, 2019 Background: Laparoscopic surgery (LAS) for T4 rectal cancer (RC) is still controversial. This study aims to compare LAS with conventional open surgery in patients with T4 RC.
Xubing Zhang +5 more
doaj +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Are “European” Scrotal Hernias Repairable With the Minimal Open Pre-Peritoneal Technique?
Journal of Abdominal Wall SurgeryBackgroundMinimally invasive open preperitoneal techniques are an alternative in groin hernia repair. Scrotal hernias (SH) are frequently difficult to repair laparoscopically, resulting in a significant conversion rate.MethodsThe aim of this exploratory ...
Marc Soler, Jean Francois Gillion
doaj +1 more source
Theory and Practice in the Use of a Pump-Oxygenator for Open Intracardiac Surgery [PDF]
, 1957 John W. Kirklin +2 more
openalex +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Conventional and/or laparoscopic rectal cancer surgery: what is the current evidence?
Innovative Surgical Sciences, 2016 Despite many years of experience with laparoscopic procedures in rectal cancer, the superiority of minimally invasive approaches has been questioned especially in recent years.
Mik Michal, Dziki Lukasz, Dziki Adam
doaj +1 more source
EXPERIENCES USING THE PUMP-OXYGENATOR FOR OPEN CARDIAC SURGERY IN MAN [PDF]
, 1957 David Mendelsohn +4 more
openalex +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source