Results 61 to 70 of about 1,821,718 (352)

Minimally Invasive versus Conventional Open Surgery for Fixation of Spinal Fracture in Ankylosed Spine [PDF]

Malaysian Orthopaedic Journal, 2020
INTRODUCTION: This was a retrospective study aimed to investigate the perioperative outcomes of long construct minimally invasive spinal stabilisation (MISt) using percutaneous pedicle screws (PPS) versus conventional open spinal surgery in the treatment
Chung WH, Ng WL, Chiu CK, Chan CYW, Kwan MK   +4 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Single-center experience in the treatment of visceral artery aneurysms [PDF]

, 2019
Background: Visceral artery aneurysms (VAAs), although rare, represent a life-threatening disease with high mortality rates. With the more frequent use of diagnostic tests, there has been an incidental detection of these lesions which are mostly ...
Di Girolamo, A., Gattuso, R., Giglio, A., Gossetti, B., Irace, L., Martinelli, O.   +5 more
core   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

A randomized trial of laparoscopic versus open surgery for rectal cancer. [PDF]

, 2017
Background Laparoscopic resection of colorectal cancer is widely used. However, robust evidence to conclude that laparoscopic surgery and open surgery have similar outcomes in rectal cancer is lacking.
Abis, Gabor A., Andersson, John, Angenete, Eva, Bemelman, Willem A., Bonjer, H.Jaap, COLOR II Study Group, Cuesta, Miguel A., de Lange-de Klerk, Elly S., Deijen, Charlotte L., Fuerst, Alois, Haglind, Eva, Lacy Fortuny, Antonio Ma. de, Rosenberg, Jacob, van der Pas, Martijn H.   +13 more
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Conscious surgery: influence of the environment on patient anxiety [PDF]

, 2008
Aims: i) To investigate anxiety arising from the experience of the clinical environment during surgery under local/ regional anaesthesia and, ii) to uncover the specific aspects patients find anxiety provoking and possibly dissuade them from opting for ...
Beals, Bhattarai, Birch, Brown, Callesen, Chit Ying, Clark, Clements, Costa, Crockett, De Andres, Essex-Lopresti, Faymonville, Field, Fung, Gajraj, Gajraj, Gillies, Gilmartin, Gnanalingham, Hankela, Howat, Jacquet, Jakobsen, Johansson, Kennedy, Kim, Koch, Koscielniak-Nielsen, Lack, Lee, Leinonen, Leinonen, Lepage, Liu, Man, Matthey, Mauleon, McKenna, Mitchell, Mitchell, Mitchell, Mitchell, Mokashi, Moon, Nijkamp, Pandit, Papanikolaou, Parroy, Raeder, Rees, Rhodes, Royal College of Surgeons of England, Rudolfsson, Shevde, Sri-Ram, Stoddard, Ternisien, Thorp, Tong, Twersky, Ward, Whittle, Zanchetta   +63 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Dehn surgery, rational open books and knot Floer homology

, 2012
By recent results of Baker--Etnyre--Van Horn-Morris, a rational open book decomposition defines a compatible contact structure. We show that the Heegaard Floer contact invariant of such a contact structure can be computed in terms of the knot Floer ...
Hedden, Matthew, Plamenevskaya, Olga
core   +1 more source

'I'd kill anyone who tried to take my band away' : obesity surgery, critical fat politics and the 'problem' of patient demand [PDF]

, 2012
Obesity surgery is commonly figured within Fat Studies as the violent mutilation of the fat body, and as the unjustifiable apotheosis of the war on obesity.
Throsby, Karen
core   +1 more source