Results 101 to 110 of about 3,275,591 (372)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
CDA Generation and Integration for Health Information Exchange Based on Cloud Computing System
IEEE Transactions on Services Computing, 2016 Successful deployment of Electronic Health Record helps improve patient safety and quality of care, but it has the prerequisite of interoperability between Health Information Exchange at different hospitals.
Sung Hyun Lee, Joon Hyun Song, I. Kim
semanticscholar +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
GATOR-V: Accelerating the RISC-V Confidential Computing Ecosystem With a Production-Grade TEE
IEEE AccessTrusted Execution Environments (TEEs) have become essential for securing sensitive computations across modern computing platforms. While the open RISC-V architecture offered promising opportunities for security innovation, the ecosystem had lacked a ...
Marouene Boubakri, Belhassen Zouari
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Cloud computing con herramientas open-source para Internet de las cosas
Maskana, 2015 RESUMEN Uno de los componentes de un sistema de telemetría basado en Internet de las Cosas (IoT) es Cloud Computing; este está formado por un servidor o conjunto de servidores interconectados que involucran hardware y software para ofrecer servicios de ...
Ariel M. Campoverde +2 more
doaj
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
System and application of video surrveillance based on edge computing
Dianxin kexue, 2020 With the popularization of video surveillance systems and the diversification of their applications,traditional data processing methods using cloud computing to handle all the computations are more and more unsustainable.Edge computing pre-processes ...
Sanming PAN, Mingqiang YUAN
doaj +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source