Results 201 to 210 of about 1,717,601 (330)

Multi-parameter and multi-objective collaborative optimization of a suspended monorail vehicle addressing its strongly coupled nonlinear characteristics. [PDF]

Sci Rep
Jiang Y, Zhang S, Liu W, Chen R, Wang Q.
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Computer-Vision- and Edge-Enabled Real-Time Assistance Framework for Visually Impaired Persons with LPWAN Emergency Signaling. [PDF]

Sensors (Basel)
Alwakid GN, Humayun M, Ahmad Z.
europepmc   +1 more source

Towards Sustainable Computing: Exploring Energy Consumption Efficiency of Alternative Configurations and Workloads in an Open Source Messaging System [PDF]

Voreakou, Maria, Kousiouris, George, Nikolaidou, Mara   +2 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Open and shared sustainable mega-constellation. [PDF]

Natl Sci Rev
Yang J, Qin J, Guo X, Yang Z, Ye G, Li X, Ma X, Liu S, Liu S, Li X, Meng Z, Zhou C, Qu Z, Hu M, Chen J.   +14 more
europepmc   +1 more source

VAWS: Constructing Trusted Open Computing System of MapReduce with Verified Participants

, 2014
Yan Ding, Huaimin Wang, Lifeng Wei, Chen Song-zheng, Hongyi Fu, Xinhai Xu   +5 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Can neuromorphic computing help reduce AI's high energy cost? [PDF]

Proc Natl Acad Sci U S A
Ornes S.
europepmc   +1 more source

PAD Cluster: An Open, Modular and Low Cost High Performance Computing System

, 1999
Volnys Borges Bernal, Sérgio Takeo Kofuji, Guilherme Matos Sipahi, Allan G. Anderson, Márcio Lobo Netto   +4 more
openalex   +2 more sources