Results 241 to 250 of about 1,717,601 (330)

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations. [PDF]

Int J Numer Method Biomed Eng
Bucelli M, Dede L.
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Editorial: Algorithm-hardware co-optimization in neuromorphic computing for efficient AI. [PDF]

Front Neurosci
Yousefzadeh A, Patiño-Saucedo A, Croon G, Sifalakis M.   +3 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

An 11-qubit atom processor in silicon. [PDF]

Nature
Edlbauer H, Wang J, Huq AMS, Thorvaldson I, Jones MT, Misha SH, Pappas WJ, Moehle CM, Hsueh YL, Bornemann H, Gorman SK, Chung Y, Keizer JG, Kranz L, Simmons MY.   +14 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

High-order expansion of neural ordinary differential equation flows. [PDF]

Sci Adv
Izzo D, Origer S, Acciarini G, Biscani F.   +3 more
europepmc   +1 more source

Tandem: An Open-Source High-Performance Computing Volumetric Software to Model Sequences of Earthquakes and Aseismic Slip Across Complex Fault Systems

Alice-Agnes Gabriel, Piyush Karki, Yohai Magen, Bar Oryan, Thomas Ulrich, Jeena Yun, Dave May   +6 more
openalex   +2 more sources

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source