Results 121 to 130 of about 488,632 (276)

Construction and evaluation of a finger motor feedback system to improve finger dexterity

Frontiers in Neuroergonomics
IntroductionRecently, a link has been established between cognitive function and hand dexterity in older adults. Declines in cognitive function have been shown to impair performance in finger tapping movements.
Shingo Takahashi, Noriko Sakurai, Yuki Kuroiwa, Daishi Takahashi, Naoki Kodama   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Organic farm incomes in England and Wales 2001/02 [PDF]

, 2004
Financial results from research work carried out for the Department of Environment, Food and Rural Affairs (DEFRA) by the Organic Farming Research Unit at the IRS, UWA on the economic performance of organic farms in 2001/02 are presented in this report ...
Fowler, Sue, Jackson, Andrew, Lampkin, Nicolas   +2 more
core  

Detection of subthreshold pulses in neurons with channel noise

, 2008
Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron.
A. L. Hodgkin, D. Paré, E. Schneidman, G. Svirskis, J. A. White, J. Rinzel, Lianchun Yu, P. Dayan, S. A. Roy, S. Schreiber, Shao-Meng Qin, W. C. Stacey, W. C. Stacey, W. C. Stacey, Yong Chen   +14 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Investigation of Factors Influencing Solenoid Valve Speed Response Characteristics of the Common Rail Injector

Machines
The dynamic injection characteristics of high-pressure common rail fuel injection systems are determined by the speed response performance of the solenoid valve. A simulation model has been established for investigating the influence mechanism and change
Yun Bai, Chengda Du, Qiang Sun, Shi Bu, Ao Wang   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Numerical Investigation of the Trade-Off Between Sound Insulation and Air Ventilation for a Partially Open Door

Eng
As urban buildings become increasingly dense, indoor personnel are often exposed to noise disturbances from adjoining rooms which can reduce working efficiency and affect mental health.
Jizhou Liu, Xu Li, Ming Li, Jiying Liu
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source