Results 41 to 50 of about 488,632 (276)

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Simulation and Analysis of Opening and Closing Dynamic Process of Spring Safety Valve

Journal of Harbin University of Science and Technology
To study the opening and closing performance of safety valve，this paper uses mathematical modeling method to simulate and analyze its performance. First，according to the working principle of safety valve，the main moving parts inside the
YAN Xu, XU Jiao, LI Zhonggang, YU Guangbin, JIA Jianbo   +4 more
doaj   +1 more source

A Hybrid Open/Closed-Loop μ Control Method for Achieving Consistent Transient Performance in Turbofan Engines

Actuators
The inconsistency in acceleration and deceleration performance between high and low altitudes is a significant challenge in aircraft engine control today. In the past, neither open-loop fuel–air ratio control nor closed-loop N-dot control could resolve this issue perfectly; the difference in acceleration and deceleration performance between high and ...
Yifu Long, Xi Wang, Jiashuai Liu
openaire   +2 more sources

Non-linear temperature-dependent curvature of a Phase Change Composite Bimorph beam [PDF]

, 2017
Bimorph films curl in response to temperature. The degree of curvature typically varies linearly with temperature and in proportion to the difference in thermal expansion of the individual layers.
Blonder, Greg
core  

Scallop swimming kinematics and muscle performance: modelling the effects of "within-animal" variation in temperature sensitivity [PDF]

, 2005
Escape behaviour was investigated in Queen scallops (Aequipecten opercularis) acclimated to 5, 10 or 15 degrees C and tested at their acclimation temperature.
Alexander RM, Anderson EJ, Bailey DM, Bailey DM, Beddow TA, Bennett AF, Cheng J-Y, Cheng J-Y, Cheng J-Y, Daniel TL, David M. Bailey, DeMont ME, Harper DG, Ian A. Johnston, Johnson TP, Johnson TP, Joll LM, Lu YT, Manuel JL, Marsh RL, Marsh RL, Marsh RL, Mellon D, Milward A, Morton B, Navas CA, Olson JM, Peck LS, Peplowski MM, Podolsky RD, Rome LC, Thorburn IW, Vogel S, Wakeling JM, Walker JA, Weihs D   +35 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A Numerical Study on Mechanical Seal Dynamic Characteristics Within a Reactor Coolant Pump

Frontiers in Energy Research, 2022
Unstable flow within a reactor coolant pump (RCP)’s mechanical seal may cause the change of its sealing parameters, possibly threatening RCP’s safe operations.
Jun-Li Wang, Jun-Li Wang, Xing-Yuan Chen, Maxime Binama, Wen-Tao Su, Jian Wu   +5 more
doaj   +1 more source

Performance Analysis of Open–Closed Circuit Integrated Pump-Valve Collaborative Drive Multi-Actuator System

Chinese Journal of Mechanical Engineering
Abstract Load-sensing systems use a centralized power source for energy supply and multiway valves for flow distribution and suffer from excessive throttling losses and low energy efficiency. Pump-controlled systems adopt volumetric control methods to eliminate throttling losses.
Tao Liang, Long Quan, Lei Ge, Lianpeng Xia   +3 more
openaire   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Ambidextrous leadership and innovation: a process perspective and an experimental approach

Humanities & Social Sciences Communications
Ambidextrous leadership is a context-based combination of opening and closing leadership behaviors, and is thought to enhance both leader and employee behaviors in complex innovation processes.
Yiheng Xi, Li Zhou, Haiyan Wang
doaj   +1 more source