Results 141 to 150 of about 3,747,212 (287)
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Open Science, Open Data, Open Source
, 2017 Making research findings available free of charge for all readers has been a major challenge identified by the European Commission. Several initiatives have been made to facilitate scientific data to the community. But has science progresses, the volume of data and platforms where information can be found also increases.
Vos, Rutger A., Fernandes, Pedro L.
openaire +1 more source
Open data + open software = open service
, 2008 Rufus Pollock, Open Software Service Definition Launched, <em> Open Knowledge Foundation Weblog </em> , July 14, 2008.
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Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. [PDF]
, 2019 Allosteric ligands modulate protein activity by altering the energy landscape of conformational space in ligand-protein complexes. Here we investigate how ligand binding to a K+ channel's voltage sensor allosterically modulates opening of its K ...
Angueyra, Juan M +6 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
PRICE DISCOVERY IN THE PRE-OPENING PERIOD. THEORY AND EVIDENCE FROM THE MADRID STOCK EXCHANGE [PDF]
Some stock exchanges, such as the Spanish Stock Exchange and Euronext (Paris), allow traders to place orders in a ‘pre-opening’ period. Orders placed in this period are used to determine the opening price, and can be cancelled at any moment and at no ...
Carolina Manzano +2 more
core
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Open libraries: open science, open learning
CalendaUNED Library, along with the UNESCO Chair in Distance Education (CUED), will be holding the International Conference Open Libraries: open science, open learning, in Madrid, from September 30th to October 3rd. The conference will focus on research and learning in Europe and the role of university libraries as support units for universities in both ...
openaire +1 more source