Results 151 to 160 of about 3,747,212 (287)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
BEHAVIOR OF COMPOSITE I-SECTION MODIFIED REACTIVE POWDER CONCRETE BEAMS WITH ULTIMATE TORQUE
Journal of Engineering and Sustainable Development, 2016 This paper presents experimental work including the investigation of seven composite modified reactive powder concrete (MRPC) I- beams, 1300mm length, 100mm web width, and 320mm height, with and without opening tested under pure torsion. The first beam
Ali Sabah Ahmed, Redhaab Hamed Saad
doaj
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Open review, open commentary, open debate
, 2006 Andrew I. Dayton, Beyond Open Access: Open Discourse, the next great equalizer, Retrovirology, August 30, 2006.
openaire +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
ABERTURA E POBREZA: qual abertura?
Revista de Políticas Públicas, 2005 Analysis of the effects of the commercial globalization on poverty. The sharp increase in economic growth has a positive impact on poverty levels, unless inequalities also speed up sharply.
Pierre Salama
doaj
Open source, open access, open courseware...
, 2003 Peter Spotts, Who will build our digital future? <em> Christian Science Monitor </em> , December 4, 2003. Primarily about open-source software, but generalizing to other arenas in which "networks of strangers are challenging traditional firms with products that are just as good, more flexible --and often free." Spotts ...
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source