Results 241 to 250 of about 4,540,854 (335)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Compressive Failure Mechanisms of NCF Laminates with Double-Hole Defects. [PDF]

Materials (Basel)
Cai S, Yan S, Jiang L, Meng Z, Niu Y.
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Shear performance of unreinforced masonry walls with door and window openings strengthened using welded steel mesh. [PDF]

Sci Rep
Ghalla M, Bazuhair RW, Mlybari EA, Mahmoodzadeh A, Elsamak G, Yehia SA.   +5 more
europepmc   +1 more source

Organizational Responses to Environmental Demands: Opening the Black Box

, 2008
Magali A. Delmas, M. Toffel
semanticscholar   +1 more source

Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.

Cardiovascular Research, 2004
A. Halestrap, S. Clarke, S. Javadov
semanticscholar   +1 more source

School opening times and services: coronavirus : information about school opening times and their services during the coronavirus pandemic [PDF]

, 2020

core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mechanistic Insights into Lewis Acid-Catalyzed Formal [3 + 2] Cycloadditions of Aziridines: A Molecular Electron Density Theory Study. [PDF]

Molecules
Domingo LR, Pérez P, Aurell MJ.
europepmc   +1 more source