Results 41 to 50 of about 1,422,266 (292)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Diversification des élites et repositionnement organisationnel

open access: yesCahiers de la Recherche sur l'Education et les Savoirs, 2008
Whereas American implementations of affirmative action focus attention on the process of democratization in Higher Education, some European educational systems and the model of social opening policies seem up to now neglected by analysts.
Annabelle Allouch   +1 more
doaj   +1 more source

Brane Induced Gravity: From a No-Go to a No-Ghost Theorem

open access: yes, 2012
Numerous claims in the literature suggest that gravity induced on a higher co-dimensional surface violates unitarity in the weak coupling regime. However, it remained unclear, why a conserved source localized on this surface and giving rise to an induced
Berkhahn, Felix   +2 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

THE MINIMAL DEFINITION AND METHODOLOGY OF COMPARATIVE PHILOSOPHY: A REPORT FROM A CONFERENCE [abstract] [PDF]

open access: yes, 2010
In June of 2008, the International Society for Comparative Studies of Chinese and Western Philosophy (ISCWP) convened its third Constructive Engagement conference, on the theme of Comparative Philosophy Methodology.
Angle, Stephen C.
core   +1 more source

Opening Statement by the Rector of the University of Akureyri

open access: yesNordicum-Mediterraneum, 2014
The Rector of the University of Akureyri welcomes the participants in the seminar "What is Morality?" organised to honour Prof. Mikael Karlsson's 70th birthday.
Stefán B. Sigurðsson
doaj  

The primary eye care examination: Opening the case history and the patient's uninterrupted initial talking time

open access: yesJournal of Optometry, 2014
Purpose: The uninterrupted initial talking time (UITT) of optometric patients was measured in response to the clinician's opening question: “Do you have any problems with your eyes or your sight?” Methods: UITT was measured surreptitiously by the ...
Jonathan S. Pointer
doaj   +1 more source

Security in the internet of everything era - opening statement [PDF]

open access: yes, 2016
Since Nikola Tesla’s “teleautomation”, it has taken almost 80 years for the general public to experience what culminated into the Internet of Things and another ten to truly accept it.
Loukas, George, Patrikakis, Charalampos
core  

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