Results 181 to 190 of about 140,513 (304)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Long-term safety and efficacy of darvadstrocel for complex perianal fistulas in Japanese adults with Crohn's disease: 3-year follow-up results. [PDF]

Crohns Colitis 360
Mizushima T, Furukawa S, Sahara R, Ohta A, Okita Y, Ito T, Ikeuchi H, Higashi D, Sugita A, Takahashi K, Ogino T, Kiryu S, Nakaya R, Narii N, Yamaguchi T, Watanabe K, Futami K.   +16 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural behavior of reinforced concrete beams with longitudinal voids incorporating embedded steel tubes. [PDF]

Sci Rep
Fayed S, Ghalla M, Iskander Y, Bazuhair RW, Bin Mahfouz YM, Yehia SA.   +5 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mimicking a submucosal tumor: endoscopic diagnosis and treatment of multiple mucosa-encapsulated fecaliths in the rectum. [PDF]

Endoscopy
Qiao QJ, He W, Zuo Y, Liu C, Li SS, Hu CJ, Fan CQ.   +6 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

New data on <i>Wangaraneus</i> Mi, Wang & Li, 2024 (Araneae, Araneidae), with descriptions of two new species from Xizang, China. [PDF]

Zookeys
Zhu H, Wang C, Smagghe G, Mi X.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Dual-tunnel endoscopic submucosal dissection for circumferential early gastric cancer involving the pylorus and duodenal bulb. [PDF]

Endoscopy
Guo C, Wang Z, Li J, Xu M.
europepmc   +1 more source