Results 31 to 40 of about 77,555 (243)

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

The Journal of Pathology, EarlyView.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch, RM Verdijk, H Fadlelseed, TPP van den Bosch, S Owens, S Kennedy, E Kilic, E Brosens   +7 more
wiley   +1 more source

Art in the Age of Globalisation: Dialogue of Cultures (Ural Opera Ballet Theatre’s Production of the Opera Tri Sestry)

Changing Societies & Personalities, 2020
The article explores the dialogics of art and the role of art as a tool of dialogue between cultures on the example of the Ural Opera Ballet Theatre’s recent stage production of the opera Tri Sestry (Three Sisters), which demonstrates a successful ...
Andrey G. Shishkin, Olga O. Morozova
doaj   +1 more source

Quantifying the Surface Deformation of Pingos on the Alaskan North Slope Using Interferometric Synthetic Aperture Radar (InSAR)

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Pingos are large mounds with cores formed of intrusive ice that form in periglacial landscapes. These ice structures can form in regions of discontinuous permafrost, commonly as hydraulic or open‐system pingos, or in locations of continuous permafrost, commonly as hydrostatic or closed‐system pingos.
Venezia M. Follingstad, Roger J. Michaelides, Matthew R. Siegfried, Tyler M. Meng, John Bradford, Kynan H. G. Hughson, Alexia R. Kubas, Andrew Mullen, Enrica Quartini, Austin Routt, Hanna G. Sizemore, Andrei Swidinsky, Britney E. Schmidt   +12 more
wiley   +1 more source

Toward a Sustainability Standard for Cultural Organizations: Borrowing From Tourism

Sustainable Development, EarlyView.
ABSTRACT Cultural organizations are increasingly engaging with sustainability, yet they lack a sector‐specific standard to guide and institutionalize efforts as long‐term strategies. This study reviews research papers on sustainability standards in the tourism sector, a field with greater experience with such tools, and horizontally borrows insights ...
Małgorzata Ćwikła, Leticia Labaronne
wiley   +1 more source

Stress‐Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis

Small, EarlyView.
Granular hydrogels are developed to tune the yield stress levels at which 3D tissue culture matrices undergo plastic deformation. We use these materials to regulate growth‐induced stresses, with demonstrable effects on cancer spheroid invasion and brain organoid morphogenesis.
James P. W. Reeves, Sabra Rostami, Mostafa Rammal, Andrei Bocan, Paula Lépine, Matthew J. Harrington, Thomas M. Durcan, Christopher Moraes   +7 more
wiley   +1 more source

Dynamics of driven dissipative temporal solitons in an intracavity phase trap

Light: Science & Applications
Temporal cavity solitons are ultrashort optical pulses circulating in driven Kerr resonators. Their intrinsic stability and ability to generate coherent broadband frequency combs have led to breakthroughs in fields such as sensing, metrology, and signal ...
Nicolas Englebert, Corentin Simon, Carlos Mas Arabí, François Leo, Simon-Pierre Gorza   +4 more
doaj   +1 more source

Photoactivated iridium(III) complexes drive pyroptosis–necroptosis synergy for multi‐network photoimmunotherapy of renal cell carcinoma

Smart Molecules, EarlyView.
Photoactivated iridium(III) complexes trigger mitochondrial DNA leakage and Ca²⁺ efflux, simultaneously driving pyroptosis and necroptosis to synergistically enhance immunogenic cell death. This multi‐network cascade promotes dendritic cell maturation and CD8⁺ T cell activation, achieving potent photoimmunotherapy of renal cell carcinoma.
Xin Qin, Meng‐Di Chen, Wenqi Gao, Yiping Wang, Lin‐Qing Liu, Zhen Teng, Tienan Qi, Qiyuan Wang, Yuxuan Wang, Daoxiang Li, Keqiang Yan, Ling Pan, Zhongwei Zhao, Shuo Zhao, Kang‐Nan Wang, Shuai Fu, Nengwang Yu   +16 more
wiley   +1 more source

Influence of energy gap between charge-transfer and locally excited states on organic long persistence luminescence

Nature Communications, 2020
Long-persistent luminescence can be realized in all-organic systems (OLPL) but still with unsatisfactory performance. Here the authors investigate the relationships between energy levels and emission properties in a series of OLPL materials and propose a
Zesen Lin, Ryota Kabe, Kai Wang, Chihaya Adachi   +3 more
doaj   +1 more source

There Is no First Phase of the Jespersen Cycle1

Transactions of the Philological Society, EarlyView.
Abstract This paper challenges the traditional conception of the Jespersen Cycle by arguing that no ‘pure’ first phase of the cycle exists where a single negator operates without reinforcement. Drawing on historical data from Northern Italian dialects (Piedmontese, Lombard, Emilian), we demonstrate that emphatic negative structures systematically co ...
Tommaso Mattiuzzi, Cecilia Poletto
wiley   +1 more source

Sino‐Mexican Encounters Before the ‘Diplomatic Opening’: Exhibition Diplomacy and Grassroots Friendship in the 1960s

History, EarlyView.
Abstract During the 1960s, Mexico's Institutional Revolutionary Party (PRI) embraced Chinese overtures for a commercial opening as consistent with its anti‐imperialist posture, thereby foreshadowing the diplomatic opening to China in 1972. Yet this professed ideological pluralism was eclipsed by an underlying allegiance to the United States' anti ...
YIXIN TIAN
wiley   +1 more source