Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Approximating the Operating Characteristics of Bayesian Uncertainty Directed Trial Designs. [PDF]
J Stat Plan Inference, 2022 Bonsaglio M +3 more
europepmc +1 more source
Modular lightweight components for peripheral e-mobility solutions [PDF]
, 2013 Based on a comprehensive prototype, the researchers at the Otto von Guericke University systematically investigate components and system solutions within a project regarding the interplay of electric vehicles and range extenders.
Gerd, Wagenhaus +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Estimating design operating characteristics in Bayesian adaptive clinical trials. [PDF]
Can J Stat, 2022 Golchi S.
europepmc +1 more source
VICAR image processing system guide to system use [PDF]
The functional characteristics and operating requirements of the Video Image Communication and Retrieval System are ...
Seidman, J. B., Smith, A. Y.
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The predictive significance of lipid accumulation products for future diabetes in a non-diabetic population from a gender perspective: an analysis using time-dependent receiver operating characteristics. [PDF]
Front Endocrinol (Lausanne), 2023 Qiu J +7 more
europepmc +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Utility of the Brief Young Adult Alcohol Consequences Questionnaire to Identify College Students At-Risk for Alcohol Related Problems: Relative Operating Characteristics across Seven Countries. [PDF]
Subst Use Misuse, 2023 Pilatti A +21 more
europepmc +1 more source