Results 51 to 60 of about 932,981 (241)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Вестник Дагестанского государственного технического университета: Технические наукиObjective. The article examines the influence of the “man-machine-environment” system on the reliability of automated systems of internal affairs bodies of the Russian Federation.Method.
A. I. Yangirov +4 more
doaj +1 more source
Research on cloud native based distributed IoT operating system architecture
Dianxin kexue, 2022 Complex application development, various types of IoT devices, diverse network technology and different types of IoT edge are the major problems of IoT.The novel concept and architecture of the cloud native based distributed IoT operating system were ...
Nan CHEN +4 more
doaj
Plant, Soil and Environment, 2010 The paper presents selected information on the newest results of a wide investigation of the state of information and communication technologies development in agricultural production enterprises in the Czech Republic.
J. Vaněk +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Sensors, 2019 The emergence and spread of Internet of Things (IoT) technologies along with the edge computing paradigm has led to an increase in the computational load on sensor end-devices.
Roberto Rodriguez-Zurrunero +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Perancangan Aplikasi Voice Chat dengan Socket Programming pada Android untuk Jaringan Lokal
Jurnal Jaringan Telekomunikasi, 2020 Aplikasi voice chat merupakan aplikasi yang dirancang untuk menggantikan fungsi HT pada smartphone android. Selain dapat melakukan panggilan dengan suara, aplikasi ini juga dapat digunakan untuk melakukan komunikasi dengan text.
Allyza Nanda Purwari +2 more
doaj +1 more source