Results 51 to 60 of about 978,193 (268)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Wireless Sensor Network Operating System Design Rules Based on Real-World Deployment Survey

Journal of Sensor and Actuator Networks, 2013
Wireless sensor networks (WSNs) have been a widely researched field since the beginning of the 21st century. The field is already maturing, and TinyOS has established itself as the de facto standard WSN Operating System (OS).
Leo Selavo, Krisjanis Nesenbergs, Girts Strazdins, Atis Elsts   +3 more
doaj   +1 more source

Methodology for efficient Execution of SPMD applications on Multicore Clusters

Journal of Computer Science and Technology, 2011
Nowadays, the scientific applications are developed with more complexity and accuracy and these precisions need high computational resources to be executed.
Ronal Muresano
doaj  

Sequentialized Virtual File System: A Virtual File System Enabling Address Sequentialization for Flash-Based Solid State Drives

Computers
Solid-state drives (SSDs) are widely adopted in mobile devices, desktop PCs, and data centers since they offer higher throughput, lower latency, and lower power consumption to modern computing systems and applications compared with hard disk drives (HDDs)
Inhwi Hwang, Sunggon Kim, Hyeonsang Eom, Yongseok Son   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Parallel Application Signature for Performance Prediction

Journal of Computer Science and Technology, 2010
In order to measure the performance of a parallel machine, a set of application kernels as benchmarks have often been used. However, it is not always possible to characterize the performance using only benchmarks, given the fact that each one usually ...
Alvaro Wong
doaj  

Docker Performance Evaluation across Operating Systems

Applied Sciences
Docker has gained significant popularity in recent years. With the introduction of Docker Desktop for Windows and macOS, there is a need to determine the impact of the operating system on the performance of the Docker platform.
Maciej Sobieraj, Daniel Kotyński
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Methodological approach to quantitative assessment of the security of open operating systems AS of the Internal Affairs Bodies

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The article considers the provisions of the fuzzy logic approach in relation to the method of quantifying the security of open operating systems (OS) of automated systems of the internal affairs bodies of the Russian Federation (AS of the ...
A. I. Yangirov, I. M. Yangirov, E. A. Rogozin, S. B. Akhlyustin   +3 more
doaj   +1 more source