Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Advanced Langmuir Probe (LP) [PDF]
The dynamic response of the MK-2 version of the Langmuir probe amplifier was studied. The settling time of the step response is increased by: (1) stray node-to-ground capacitance at series connections between high value feedback resistors; and (2) input ...
Block, B. P. +2 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Slew Rate and Step Response of the Noninverting Structure with an Operational Amplifier
Advances in Electrical and Electronic Engineering, 2004 When a large-step input voltage is applied to an operational amplifier (OP AMP) input, the output waveform reises with a finite slope called the slex rate which is due to an amplifier input stage current limiting (Im) and because of a compensating ...
Josef Puncochar
doaj
Feasibility Study of the Use of Operational Amplifiers as Forward Gain Stages in Charge Preamplifiers and Shaping Filters for Radiation Detectors [PDF]
, 2023 A. Castoldi, C. Guazzoni, Andrea Naggi
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Design of Polymer-Based Trigate Nanoscale FinFET for the Implementation of Two-Stage Operational Amplifier [PDF]
, 2022 Jami Venkata Suman +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Active Damping of Milling Vibration Using Operational Amplifier Circuit [PDF]
, 2018 Bashir Bala Muhammad +3 more
openalex +1 more source
Design and Comparative analysis of a Two-Stage Ultra-Low-Power Subthreshold Operational Amplifier in 180nm, 90nm, and 45nm technology [PDF]
, 2021 Sumukh Nitundil +3 more
openalex +1 more source