Results 91 to 100 of about 62,185 (340)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Rotating raster generator [PDF]
, 1974 A rotating raster generator is provided which enables display of a television raster at any arbitrary roll angle. The generator includes four integrator circuits each of which receives a first voltage input corresponding to the sine or cosine of the ...
Wagner, C. A.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Design of input stage amplifier circuit for power operational amplifiers
Dianzi Jishu Yingyong, 2019 An input stage amplifier is designed for a power operational amplifier based on 70 V high voltage bipolar technology. The amplifier circuit implements a differential telescopic cascode pair using p-type JFETs.
Wang Yongyong +4 more
doaj +1 more source
A 180 nm Low-Cost Operational Amplifier for IoT Applications
, 2021 Kevin Vicuña +7 more
openalex +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Mutator Circuit for Memcapacitor Emulator Using Operational Transconductance Amplifiers
Elektronika ir ElektrotechnikaIn recent years, interest in memelements, including memcapacitors, has increased significantly following the realisation of memristors. This paper presents the design and implementation of a memcapacitor circuit based on operational transconductance ...
Mustafa Konal, Fırat Kacar
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Design Procedure of Cascaded Multilevel Inverter for High-Power Amplifier in SONAR System
EnergiesIn recent years, there has been a trend toward expanding the operating frequency range and increasing the output power of Sound Navigation and Ranging (SONAR) systems to enhance their acoustic detection capabilities.
Jejin Jang +3 more
doaj +1 more source