Results 211 to 220 of about 1,220,062 (289)

When should a public health emergency of international concern be declared? The case of the 2018-2020 Ebola outbreak in the Democratic Republic of the Congo. [PDF]

Health Policy Plan
Frossard Pagotto B.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Defining the safe operational window for holmium laser lithotripsy in impacted ureteral stones: an analysis of power, operator duty cycle, and irrigation flow. [PDF]

Sci Rep
Luo J, Li X, Ren R, Li Y, Wu H, Zhang L, Yuan R, Gong M.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Donor dependency and pandemic readiness: insights from the 2026 Ebola Bundibugyo outbreak in the East African community. [PDF]

Front Public Health
Mugisha J, Niyibizi J, Nizeyimana E, Koray MH.   +3 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Canine Tooth Microbiome Gingival Index: a new microbiome-derived measure of gingival health validated by nutritional intervention. [PDF]

Front Vet Sci
Hollar R, Cochrane CY, Green N, Coffman L, Scherl D, Badri DV.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Flexible ureterorenoscopy with holmium laser lithotripsy for ureteral calculi complicated by hydronephrosis. [PDF]

Am J Transl Res
Zhi J, Lin H, Zhang X, Sun Y, Jiang P, Feng N.   +5 more
europepmc   +1 more source