Results 61 to 70 of about 6,665 (300)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Executable Behaviour and the π-Calculus (extended abstract) [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2015
Reactive Turing machines extend classical Turing machines with a facility to model observable interactive behaviour. We call a behaviour executable if, and only if, it is behaviourally equivalent to the behaviour of a reactive Turing machine.
Bas Luttik, Fei Yang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Rate-Based Transition Systems for Stochastic Process Calculi [PDF]

open access: yes, 2009
A variant of Rate Transition Systems (RTS), proposed by Klin and Sassone, is introduced and used as the basic model for defining stochastic behaviour of processes.
De Nicola, Rocco   +8 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Operational Calculus [PDF]

open access: yes, 2013
The Operational Calculus is a construction used for analyzing the behavior of linear operators that arise in the study of ordinary and partial differential equations.
Sedberry, Trevor Lear
core  

Integral Transforms and Operational Calculus [PDF]

open access: yes, 2019
Researches and investigations involving the theory and applications of integral transforms and operational calculus are remarkably wide-spread in many diverse areas of the mathematical, physical, chemical, engineering and statistical ...
Srivastava, Hari Mohan
core   +1 more source

Operational calculus and differential equations with infinitely smooth coefficients

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1990
A subring MF of the field of Mikusiński operators is constructed as a countable union space. Some topological properties of MF are investigated. Then, the product of an infinitely differentiable function and an element of MF is given and is used to ...
Dennis Nemzer
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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