Results 21 to 30 of about 120 (102)

Cell Envelope Remodeling and Lipid Metabolism Coordinate Extracellular Vesicle Output in Mycobacterium Tuberculosis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global cause of death due to the pathogen's highly adaptive physiology and its ability to manipulate host immunity. Despite extensive study, our understanding of Mtb biology during infection remains incomplete, limiting the development of new diagnostics ...
José L. Serrano‐Mestre, Laura Lerma, Lucía Vázquez‐Iniesta, Vivian C. Salgueiro‐Toledo, Ainhoa Palacios, Sogol Alebouyeh, Andrea Doddi, Felix Elortza, Mikel Azkargorta, Leticia Sampedro, Estibaliz Atondo, Miguel Ángel Pacual‐Itoiz, Oren Mayer, Torin Westwood, William R. Jacobs Jr, Rafael Prados‐Rosales   +15 more
wiley   +1 more source

To Which Extent the Surface Water Ocean Topography (SWOT) Mission Is Currently Able to Monitor Water Surface Elevation and Extent on the French Lakes?

Earth and Space Science, Volume 13, Issue 6, June 2026.
Abstract This study (July 2023–December 2025) assesses the SWOT satellite's ability to measure water surface elevation (WSE) and surface water extent (SWE) over diverse French lakes. WSE estimates from SWOT were compared to in situ gauge data and conventional radar altimetry, while SWE was evaluated using the Global Water Watch (GWW) database.
C. Normandin, F. Frappart, C. Moisy, N. Baghdadi, B. Ygorra, L. Bourrel, P. Maisongrande, D. Leroux, J.‐F. Crétaux, J.‐P. Wigneron   +9 more
wiley   +1 more source

Optical Fiber Sensors for Safety and Maintenance Monitoring of Linear Infrastructure

Advanced Sensor Research, Volume 5, Issue 5, May 2026.
This review rigorously provides a thorough and detailed overview of the most recent innovations and advancements in the field of railway and pipeline infrastructure monitoring, accomplished through the implementation of cutting‐edge fiber sensing technologies, with a specific emphasis on its two principal technical branches, namely multipoint sensing ...
Shengnan Wu, Yue Cao, Xiaokun Qian, Jianling Wu, Armando Laudati, Vincenzo Romano Marrazzo, Maria Alessandra Cutolo, Giovanni Breglio, Andrea Cusano, Antonello Cutolo, Sailing He   +10 more
wiley   +1 more source

Photonuclear Population of 229m,gTh in Th‐Doped Crystals Toward Nuclear Clock Development

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study demonstrates a novel photonuclear approach for producing the nuclear clock isomer 229mTh in thorium‐doped crystals, overcoming current supply limitations. Through cross‐section calculations and Monte Carlo simulations, we identify optimal crystal materials and irradiation conditions, achieving high signal‐to‐noise ratios.
Hao‐Yang Lan, Di Wu, Mei‐Zhi Wang, Zhong‐Yi Chen, Jian‐Feng Lv, Yu‐Hui Xia, Zhe‐Nan Wang, Wen Luo, Xin‐Lu Xu, Xue‐Qing Yan   +9 more
wiley   +1 more source

Assessment of the Drug–Drug Interaction Potential of Lotiglipron (PF‐07081532) with Midazolam, Omeprazole, Dabigatran, Rosuvastatin, and the Oral Contraceptives Levonorgestrel and Ethinyl Estradiol

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Two Phase 1 open‐label studies were conducted in otherwise healthy participants, with BMI classified as overweight/obesity, to assess the potential of lotiglipron (a glucagon‐like peptide‐1 receptor agonist) as precipitant for pharmacokinetic (PK) drug–drug interactions (DDIs) when co‐administered with substrates of cytochrome P450 (CYP) 3A ...
Carol Cronenberger, Neeta B. Amin, Vu H. Le, Santos Carvajal‐Gonzalez, Amy L. Ashworth, Ellen C. Yi, Tilman Schuster, Yizhong Zhang, Robert C. Frederich, Gary S. Friedman, Ellen Q. Wang, Nikolaos Tsamandouras   +11 more
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Glanders: Past, Present and Future of a Neglected Zoonosis as a Threat in Veterinary and Human Health

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This review displays a comprehensive overview of glanders, including aetiology, epidemiology, pathogenesis, diagnosis, control strategies and ongoing eradication programs. It has also reviewed differential diagnosis and treatment both in animals and humans as well as organism's antimicrobial properties.
Yahya Kanani, Ahmad Oryan, Abdollah Derakhshandeh   +2 more
wiley   +1 more source

Differentiating Solar Radiation Modification Field Experiments: Scale, Technical Characteristics, and Governance Implications

Earth's Future, Volume 14, Issue 5, May 2026.
Abstract Proposed solar radiation modification (SRM) field experiments are receiving growing scientific and policy attention, with several localized experiments having occurred or under development. While they may be critical for improving technical understanding and reducing uncertainties, SRM field experiments remain controversial and inadequately ...
B. H. Redmond Roche, I. Hernandez‐Galindo, A. Määttänen, J. C. Moore, O. Boucher, B. M. Dollner, A. Duffey, B. Gasparini, J. Henneberger, A. N. Koyun, D. McGrath, I. Steinke, J. Vinders, D. Visioni, P. J. Irvine   +14 more
wiley   +1 more source

The Life Cycle of a Stratospheric Smoke Plume as Seen From EarthCARE—Tracking a Plume From Canada to Europe

Geophysical Research Letters, Volume 53, Issue 7, 16 April 2026.
Abstract At the end of May 2025, extremely strong wildfires in Canada produced several pyrocumulonimbus clouds lifting the smoke particles up to the lower stratosphere. Stratospheric aerosol optical depths of more than 2.5 were observed by the ATmospheric LiDAR (ATLID) onboard of the Earth Cloud, Aerosol and Radiation Explorer (EarthCARE) satellite ...
Moritz Haarig, Holger Baars, Leonard König, David P. Donovan, Albert Ansmann, Sergey Khaykin, Romain Ceolato, Benedikt Gast, Crisofer Jimenez, Athena A. Floutsi, Robin J. Hogan, Annabel Chantry, Fabien Marnas, Johanna Roschke, Gerd‐Jan van Zadelhoff, Ulla Wandinger   +15 more
wiley   +1 more source

Olfactory decline tracks central‐to‐peripheral spread of tau pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Olfactory decline often precedes cognitive symptoms in Alzheimer's disease (AD) and is linked to tau pathology. Yet, whether tau aggregates start in peripheral olfactory structures or spread from central regions remains debated. METHODS We analyzed 34 post mortem human olfactory bulb (OB) and 2 neuroepithelium (ONE) samples across
Kamar Bouchoucha, Lisa Collin, Céline Coquette, Lise Colmant, Emilien Boyer, Lara Huyghe, Lisa Quenon, Thomas Gerard, Yasmine Salman, Valérie Hox, Pascal Kienlen‐Campard, Bernard Hanseeuw, Anabelle Decottignies, Caroline Huart   +13 more
wiley   +1 more source