Results 51 to 60 of about 42,254 (264)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Direct Method to Solve Differential-Algebraic Equations by Using the Operational Matrices of Chebyshev Cardinal Functions

Journal of Mathematical Extension, 2013
A new and effective direct method to determine the numerical solution of linear and nonlinear differential-algebraic equations (DAEs) is proposed. The method consists of expanding the required approximate solution as the elements of Chebyshev cardinal
M. Heydari, G. Barid Loghmani, S. M. Hosseini, S. M. Karbassi   +3 more
doaj  

Solutions for Linear Fractional Differential Equations with Multiple Constraints Using Fractional B-Poly Bases

Mathematics
This study presents an innovative numerical method for solving linear fractional differential equations (LFDEs) using modified Bernstein polynomial bases.
Md. Habibur Rahman, Muhammad I. Bhatti, Nicholas Dimakis   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On a Biparametric Appell Extension: Analytical Properties and Structural Analysis

Axioms
This paper introduces and investigates a novel two-parameter sequence, termed the biparametric Appell extension (B-App-Ex) and denoted by Bn(x;λ,α). Standard classical Appell sequences often lack sufficient structural parameters, which can limit their ...
Hany Mostafa Ahmed
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Shifted Pell–Lucas Polynomial-Based Algorithms for Fractional and Classical Rosenau–Hyman Models

Fractal and Fractional
This paper introduces two numerical algorithms for solving the fractional and classical Rosenau–Hyman equations. Certain shifted Pell–Lucas polynomials (SPLPs) are employed.
Waleed Mohamed Abd-Elhameed, Hassan M. Alshehri, Mohammed H. Alharbi, Omar Mazen Alqubori, Amr Kamel Amin, Ahmed Gamal Atta   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source