Results 81 to 90 of about 42,254 (264)

Numerical Solution of Space-time Fractional two-dimensional Telegraph Equation by Shifted Legendre Operational Matrices

پژوهش‌های ریاضی, 2018
Fractional differential equations (FDEs) have attracted in the recent years a considerable interest due to their frequent appearance in various fields and their more accurate models of systems under consideration provided by fractional derivatives.
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doaj  

Chebyshev wavelets collocation method for simulating a two-phase flow of immiscible fluids in a reservoir with different capillary effects

Journal of Petroleum Exploration and Production Technology, 2019
At least in the last 10 years, considerable effort has been given to studying the dynamics of fluid flow in porous media. The phenomena is widely applicable in many areas of science and engineering.
Gaston Edem Awashie, Peter Amoako-Yirenkyi, Isaac Kwame Dontwi   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Numerical Solution for Gas Dynamics Equation Involving Caputo-Time Fractional Derivative Using a Family of Shifted Chebyshev Polynomials

Fractal and Fractional
This study develops an effective numerical method for addressing the time-fractional gas dynamics equation formulated with the Caputo time-fractional derivative.
Waleed Mohamed Abd-Elhameed, Ahmed H. Al-Mehmadi, Naher Mohammed A. Alsafri, Omar Mazen Alqubori, Amr Kamel Amin, Ahmed Gamal Atta   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Correction: New Operational Matrices for Solving Fractional Differential Equations on the Half-Line. [PDF]

PLoS One, 2015
Bhrawy AH, Taha TM, Alzahrani EO, Baleanu D, Alzahrani AA.   +4 more
europepmc   +2 more sources

Novel Approach by Shifted Fibonacci Polynomials for Solving the Fractional Burgers Equation

Fractal and Fractional
This paper analyzes a novel use of the shifted Fibonacci polynomials (SFPs) to treat the time-fractional Burgers equation (TFBE). We first develop the fundamental formulas of these polynomials, which include their power series representation and the ...
Mohammed H. Alharbi, Abdullah F. Abu Sunayh, Ahmed Gamal Atta, Waleed Mohamed Abd-Elhameed   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Wavelet Collocation Method for Solving Multiorder Fractional Differential Equations

Journal of Applied Mathematics, 2012
The operational matrices of fractional-order integration for the Legendre and Chebyshev wavelets are derived. Block pulse functions and collocation method are employed to derive a general procedure for forming these matrices for both the Legendre and the
M. H. Heydari, M. R. Hooshmandasl, F. M. Maalek Ghaini, F. Mohammadi   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source