Results 91 to 100 of about 697,634 (341)

Knife-edge based measurement of the 4D transverse phase space of electron beams with picometer-scale emittance

, 2019
Precise manipulation of high brightness electron beams requires detailed knowledge of the particle phase space shape and evolution. As ultrafast electron pulses become brighter, new operational regimes become accessible with emittance values in the ...
Durham, Daniel, Filippetto, Daniele, Ji, Fuhao, Minor, Andrew, Musumeci, Pietro, Navarro, Jorge Giner   +5 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Application of Fractional Calculus for Parameter Estimation of Nonlinear Wiener Systems With Time Delay

IEEE Access
The parameter identification technique for a fractional-order Wiener system with time delay is proposed using the Haar wavelet operational matrices. The method is applicable to lower and higher-order Wiener systems, where the order could be an integer or
Kajal Kothari
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A Reliable Method for Solving Fractional Sturm–Liouville Problems

Mathematics, 2018
In this paper, a reliable method for solving fractional Sturm–Liouville problem based on the operational matrix method is presented. Some of our numerical examples are presented.
M. M. Khashshan, Muhammed I. Syam, Ahlam Al Mokhmari   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Elementary Matrix Operations

, 2016
The mathematics for studying the properties of matrices is called matrix algebra or linear algebra. This first chapter treats the introductory part of matrix algebra required for learning multivariate data analysis.
openaire   +2 more sources

Bernoulli Wavelets Method for Solution of Fractional Differential Equations in a Large Interval

پژوهش‌های ریاضی, 2016
In this paper, Bernoulli wavelets are presented for solving (approximately) fractional differential equations in a large interval. Bernoulli wavelets operational matrix of fractional order integration is derived and utilized to reduce the fractional ...
E Keshavarz, Y Ordokhani
doaj  

Extension of Operational Matrix Technique for the Solution of Nonlinear System of Caputo Fractional Differential Equations Subjected to Integral Type Boundary Constrains. [PDF]

Entropy (Basel), 2021
Khalil H, Khalil M, Hashim I, Agarwal P.
europepmc   +1 more source