Results 101 to 110 of about 697,634 (341)

Design review package for the on-site monitor for solar heating and cooling systems [PDF]

open access: yes
The performance specification and verification matrix for the on-site monitor (OSM) is presented. The OSM is a portable device which, when connected to the Site Data Acquisition subsystem, allows readout of data on solar heating and cooling operational ...

core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Euler Operational Matrix of Integration and Collocation Method for Solving Functional Integral Equations [PDF]

open access: yesSahand Communications in Mathematical Analysis
In this paper, the functional Volterra integral equations of the Hammerstein type are studied. First, some conditions that ensure the existence and uniqueness of the solutions to these equations within the space of square-integrable functions are ...
Sohrab Bazm, Fatemeh Pahlevani
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

An efficient computer based wavelets approximation method to solve Fuzzy boundary value differential equations

open access: yesNonlinear Engineering, 2016
In the present work a wavelets approximation method is employed to solve fuzzy boundary value differential equations (FBVDEs). Essentially, a truncated Legendre wavelets series together with the Legendre wavelets operational matrix of derivative are ...
Alam Khan Najeeb, Razzaq Oyoon Abdul
doaj   +1 more source

An Operational Matrix of Fractional Derivatives of Laguerre Polynomials

open access: yesWalailak Journal of Science and Technology, 2014
In this paper, we derive the Laguerre operational matrix (LOM) of fractional derivatives, which is applied together with the spectral tau method for numerical solution of general linear multi-term fractional differential equations (FDEs) on the half line.
Mohamed Abdelhalim ABDELKAWY   +1 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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