Results 101 to 110 of about 701,369 (343)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Design review package for the on-site monitor for solar heating and cooling systems [PDF]

open access: yes
The performance specification and verification matrix for the on-site monitor (OSM) is presented. The OSM is a portable device which, when connected to the Site Data Acquisition subsystem, allows readout of data on solar heating and cooling operational ...

core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

A new operational matrix method to solve nonlinear fractional differential equations

open access: yesNonlinear Engineering
This study aims to propose novel Zernike wavelets and a new method based on the operational matrices for solving nonlinear fractional differential equations. First, non-orthogonal Zernike wavelets are introduced using the Zernike polynomials. Then, a new
Hedayati Maryamsadat, Ezzati Reza
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Traffic matrix estimation on a large IP backbone: a comparison on real data [PDF]

open access: yes, 2004
This paper considers the problem of estimating the point-to-point traffic matrix in an operational IP backbone. Contrary to previous studies, that have used a partial traffic matrix or demands estimated from aggregated Netflow traces, we use a unique ...
Gunnar, Anders   +2 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Design strategies for low embodied energy and greenhouse gases in buildings: analyses of the IEA Annex 57 case studies [PDF]

open access: yes, 2014
This paper introduces the IEA Annex 57 case study method, consisting of a format for describing individual case studies and an evaluation matrix covering all case studies.
Birgisdottir, H.   +8 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

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