Results 181 to 190 of about 2,531,355 (284)

Advancing Global Health Security through Rapid Operational Research on Diagnostics during Outbreaks. [PDF]

Am J Trop Med Hyg
Boro E, Hoppe A, Bausch DG.
europepmc   +1 more source

Defining operational research priorities to improve malaria control and elimination in sub-Saharan Africa: results from a country-driven research prioritization setting process. [PDF]

Malar J, 2023
Tine R, Herrera S, Badji MA, Daniels K, Ndiaye P, Smith Gueye C, Tairou F, Slutsker L, Hwang J, Ansah E, Littrell M, Malaria Operational Research Prioritization Partnership.   +11 more
europepmc   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Using operational research as a tool to improve eye health services and systems in low-and middle-income settings: lessons from India and Nepal. [PDF]

BMC Med Educ
Priya R, Bassett KL, Murthy GVS, O'Brien KS, Judson K, Gilbert SS, Chaudhuri S, Agiwal V.   +7 more
europepmc   +1 more source

Operational Research to Inform Programmatic Approaches to the Management of Tuberculosis in Uzbekistan. [PDF]

Int J Environ Res Public Health, 2021
Gadoev J, Harries AD, Korotych O, Kumar AMV, Dadu A, Kuppens L, Parpieva N, Abdusamatova B, Yedilbayev A, Dara M.   +9 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Spatial Analysis of Travel Distances for Persons with Common Cancers Seeking Care at a Tertiary Care Facility in South India: An Operational Research. [PDF]

Asian Pac J Cancer Prev
Devaraj L, Devasia J, Sahu SK, Karunanithi G, Ganesn P, Auroprem SP, Olickal JJ, Thulasingam M.   +7 more
europepmc   +1 more source

Operational Research: A multidisciplinary discipline [PDF]

, 2005
Vidal, Rene Victor Valqui
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Operational Research Improves Compliance with Treatment Guidelines for Empirical Management of Urinary Tract Infection: A Before-and-After Study from a Primary Health Facility in Ghana. [PDF]

Trop Med Infect Dis
Boateng E, Owusu H, Thekkur P, Hedidor GK, Corquaye O, Opare-Addo MNA, Nkansah FA, Vandyck-Sey P, Ankrah D, Ofei-Palm CNK.   +9 more
europepmc   +1 more source