Results 251 to 260 of about 366,356 (316)

Near-Real-Time Clinical Trial Accrual Dashboard in a National Cancer Institute-Designated Cancer Center: Mixed Methods Implementation Study. [PDF]

JMIR Med Inform
Pepper S, Ratnayake I, Mahmudur Rahman M, Islam Talukder MR, Islam Saif MS, Rippee O, Jayawardhana A, Lin T, Streeter N, Gajewski B, Wick J, Mayo MS, Mudaranthakam DP.   +12 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Early Anomaly Pre-Warning of Buried Pipelines via Dynamic Acceleration Signals: An ICEEMDAN-LSTM Framework. [PDF]

Sensors (Basel)
Guo YQ, Zhu ZX, Xia ZH, Zang XL, Li JB.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Design of a mixed reality-based digital twin human-machine interaction system for special working conditions. [PDF]

Front Robot AI
Li S, Hu Y, Li H, Xu J, Li M, Zhang Y, Ren Q.   +6 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Liberation mathematics I: the behavioral and consciousness definition of perpetual self-transcendence. [PDF]

Front Psychol
Samanta S.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Early olfactory pre-conditioning during sensitive developmental periods is associated with enhanced detection performance in working dogs. [PDF]

Vet Res Commun
Durán-Arroyo G, Cuadrado-Gordillo I, Bormann DA, Fernández MJ, Pichilingue-Chalco EJ, Grandjean D.   +5 more
europepmc   +1 more source