Results 171 to 180 of about 29,013 (211)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Additive Manufacturing of High‐Performance Polymers for Extreme Environments

Advanced Science, EarlyView.
Additive manufacturing of high‐performance polymers for extreme environments is critically reviewed through an integrated chemistry‐processing‐structure‐property‐qualification framework. The review compares fused filament fabrication, selective laser sintering, and direct ink writing, linking rheology and thermal history to crystallization, defect ...
Md Tofazzal Hossain, Mohammed Intishar Nur, Md Shajedul Hoque Thakur, Indranil Dey, Md Mesbahul Maruf, Md Jahid Hasan, Suryasarathi Bose, Muhammad M. Rahman   +7 more
wiley   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

Precise Control of Charge–Structure Coupling in Polyamide Membranes for Mono‐ and Divalent Ion Separation

Advanced Science, EarlyView.
A zwitterionic copolymer, Poly(2‐methacryloyloxyethyl phosphorylcholine‐co‐2‐aminoethyl methacrylate hydrochloride) (P(MPC‐co‐AEMA)) copolymers, with tunable MPC/AEMA ratios, is grafted onto the polyamide (PA) selective layer via secondary interfacial polymerization. Balancing reactive anchoring segments (AEMA) and zwitterionic segments (MPC) regulated
Shaofan Duan, Shuai Jiang, Feidong Yang, Yuxuan Feng, Yongxuan Shi, Pengfei Zhang, Mengyang Hu, Yuqing Lin, Tae Hoon Lee, Kecheng Guan, Keizo Nakagawa, Tomohisa Yoshioka, Hideto Matsuyama, Eiji Kamio   +13 more
wiley   +1 more source

Scalable Multilayer PTFE‐Reinforced Membranes for Durable, High‐Current‐Density Hydroxide Exchange Membrane Water Electrolysis in Dilute Alkali

Advanced Science, EarlyView.
Low‐Tg HEMs are designed to improve membrane‐electrode adhesion by promoting intimate contact with catalyst layers. After hydration, the membrane develops a hydrogel‐like network that supports water uptake and ion transport while retaining mechanical robustness.
Zhiwei Ren, Yun Zhao, Rui Zhang, Tao Wei, Yingran Zhu, Yangkai Han, Tongzhou Li, Haitao Zhang, Zhigang Shao   +8 more
wiley   +1 more source

A Superstrong and Ultratough Stretchable Electronic Conductor With Ultradurable Strain‐Insensitive Electromechanical Performance

Advanced Science, EarlyView.
We report a superstrong, ultratough, and fatigue‐resistant stretchable electronic conductor (SEC) integrating a viscoplastic quasi‐solid LM‐Ag alloy with a supramolecular elastomer. Unlike conventional LM, the alloy exhibits thixotropic flow, reduced surface tension, and enhanced interfacial interactions with the elastomer.
Yuxing Shan, Dong Lei, Chengzhi Huang, Chunhong Gong, Jingwei Zhang, Xiaokong Liu   +5 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

Advanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong, Yitong Zhu, Tingting Ji, Yuanyuan Qin, Shijin Peng, Yu Zhang, Yuhang Guo, Tiange Zhang, Chunchen Liu, Bo Li, Lei Zheng, Ye Zhang, Xiaohui Yan   +15 more
wiley   +1 more source

Tailoring Structure–Property Relationships in π‐Conjugated Heterocyclic Poly(arylene alkylene) Anion‐Exchange Membranes for High‐Performance Water Electrolysis

Advanced Science, EarlyView.
From passive to active ion transport: π‐conjugated heterocycles reconfigure the hydration environment and microphase morphology of p‐terphenyl‐based anion‐exchange membranes, enabling fast hydroxide transport and high‐performance water electrolysis. ABSTRACT Anion‐exchange membrane water electrolysis (AEMWE) is a promising technology for sustainable ...
Qian Wang, Riyang Huang, Wenzhe Zhao, Si Chen, Yunpeng Guo, Yang Wu, Yun Zhao, Patric Jannasch, Jingshuai Yang   +8 more
wiley   +1 more source

Achieving High‐Instantaneous Pulse Power in Contact‐Separation TENG via Series Capacitive Voltage Control Architecture

Advanced Science, EarlyView.
Conventional contact‐separation triboelectric nanogenerators generate high voltage but deliver limited power due to premature charge dissipation. Here, a capacitive charge reservoir architecture decouples charge accumulation from discharge triggering, enabling sequential voltage amplification via floating‐layer capacitive coupling.
Ajay Haridas CP, Prosenjit Das, Kinsuk Naskar, Titash Mondal   +3 more
wiley   +1 more source