Results 41 to 50 of about 24,901,720 (376)

An Integrated Fermatean Fuzzy Multi-attribute Evaluation of Digital Technologies for Circular Public Sector Supply Chains

open access: yesInternational Journal of Computational Intelligence Systems, 2023
The barriers to implementing circular supply chains are well explored, but very little is provided to understand how these barriers play in public sector supply chains.
Samantha Shane Evangelista   +6 more
doaj   +1 more source

State Complexity of Catenation Combined with Star and Reversal [PDF]

open access: yes, 2010
This paper is a continuation of our research work on state complexity of combined operations. Motivated by applications, we study the state complexities of two particular combined operations: catenation combined with star and catenation combined with ...
Bo Cui   +5 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

A comparative study of the capability of alternative mixed integer programming formulations

open access: yesTechnological and Economic Development of Economy, 2018
In selecting the best mixed integer linear programming (MILP) formulation the important issue is to figure out how to evaluate the performance of each candidate formulation in terms of selected criteria.
Baris Kececi   +3 more
doaj   +1 more source

Economy of Scale in Russian Retail Electricity Market: On One Natural and One Unnatural Monopoly [PDF]

open access: yesProstranstvennaâ Èkonomika, 2018
The paper presents an econometric analysis of the economy of scale in retail electricity markets in respect to the main service providers in the retail markets, which are territorial distribution grid companies and energy sales companies – guaranteeing ...
Maxim Valerievich Kukoverov
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Modelling Distribution Routes in City Logistics by Applying Operations Research Methods

open access: yesPromet (Zagreb), 2022
The article focuses on the up-to-date subject from the practical as well as scientific point of view. It specifically discusses a proposal of an approach concerning transport or distribution problems in the range of city logistics and investigates ...
Ondrej Stopka
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Some Applications of Polynomial Optimization in Operations Research and Real-Time Decision Making [PDF]

open access: yes, 2015
We demonstrate applications of algebraic techniques that optimize and certify polynomial inequalities to problems of interest in the operations research and transportation engineering communities.
Ahmadi, Amir Ali, Majumdar, Anirudha
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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