Results 181 to 190 of about 2,025,350 (343)

Concurrent posterior vault expansion and extradural Chiari decompression in syndromic and non-syndromic craniosynostosis: a case series. [PDF]

open access: yesChilds Nerv Syst
Ryan IA   +7 more
europepmc   +1 more source

Feasibility of a Co-operative Winery [PDF]

open access: yes
The number of operating wineries in the United States has doubled during the past decade. Most of this growth has been due to a large number of entrepreneurial landowners developing their own small acreage vineyards and trying to branch into winemaking ...
Hill, Amanda   +2 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Metastatic melanoma of the skin: Surgical treatment [PDF]

open access: yesVojnosanitetski Pregled, 2003
Panajotović Ljubomir
doaj   +1 more source

Intra-operative detection of cholecystohepatic duct during cholecystectomy: a case report. [PDF]

open access: yesJ Surg Case Rep
Bowman MA   +5 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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